Oelberg D G, Lester R
Annu Rev Med. 1986;37:297-317. doi: 10.1146/annurev.me.37.020186.001501.
Concepts regarding the pathogenesis of cholestasis continue to evolve as investigational techniques improve and molecular mechanisms of bile formation are clarified. With the accumulation of information it is becoming increasingly evident that cholestasis results from not one but multiple disturbances in the sequence of events responsible for bile production. In addition to the inhibition of bile flow attributable to initiating events, cholestasis itself may inhibit bile flow by altering the intra- and extracellular environments of liver cells. Many questions about cholestasis remain unanswered, but future directions for research are suggested by the information currently available.
随着研究技术的改进以及胆汁形成的分子机制得以阐明，关于胆汁淤积发病机制的概念也在不断演变。随着信息的积累，越来越明显的是，胆汁淤积并非由导致胆汁生成的一系列事件中的单一干扰因素引起，而是由多种干扰因素所致。除了起始事件导致胆汁流动受到抑制外，胆汁淤积本身可能通过改变肝细胞的细胞内和细胞外环境来抑制胆汁流动。关于胆汁淤积仍有许多问题尚未得到解答，但目前可得的信息为未来的研究方向提供了线索。
