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寨卡病毒蛋白与人类神经蛋白序列相似性的见解。

Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins.

作者信息

Marsakatla Prasanna, Suneetha Sujai, Lee Joshua, Swaminathan Paari Dominic, Vasudevan Logeshwaran, Supriya Rachael, Suneetha Lavanya Moses

机构信息

CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad -500029, Telangana, India.

York University, Department of Science, 4700 Keele St, Toronto, ON M3J 1P3, Canada.

出版信息

Bioinformation. 2018 May 31;14(5):194-200. doi: 10.6026/97320630014194. eCollection 2018.

DOI:10.6026/97320630014194
PMID:30108415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6077820/
Abstract

Massive peptide sharing between the Zika virus polyprotein and host tissue proteins could elicit significant host-pathogen interactions and cross-reactions leading to autoimmune diseases. This study found similarities in the Zika V proteins and human nerve tissue proteins. 63 human nerve proteins were screened for similarities with the Zika V of which Neuromodulin, Nestin, Galanin, Bombesin, Calcium-binding protein were found to have similarities to the Zika V poly protein C at different sequence regions. These sequence similarities could be significant in regulating pathogenic interactions/autoimmunity, as Polyprotein C is known to be a virulent factor.

摘要

寨卡病毒多聚蛋白与宿主组织蛋白之间大量的肽共享可能引发显著的宿主-病原体相互作用和交叉反应，从而导致自身免疫性疾病。本研究发现寨卡病毒V蛋白与人类神经组织蛋白存在相似性。对63种人类神经蛋白进行了与寨卡病毒V蛋白相似性的筛选，其中发现神经调节蛋白、巢蛋白、甘丙肽、蛙皮素、钙结合蛋白在不同序列区域与寨卡病毒V多聚蛋白C具有相似性。由于已知多聚蛋白C是一种毒力因子，这些序列相似性在调节致病性相互作用/自身免疫方面可能具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b45a8635e125/97320630014194F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/24532e4ff299/97320630014194F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b50fdedfe39a/97320630014194F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b7322e2b8924/97320630014194F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/2516eae25a8a/97320630014194F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b7ebcd3eaa59/97320630014194F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/075e4db5af6f/97320630014194F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b45a8635e125/97320630014194F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/24532e4ff299/97320630014194F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b50fdedfe39a/97320630014194F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b7322e2b8924/97320630014194F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/2516eae25a8a/97320630014194F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b7ebcd3eaa59/97320630014194F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/075e4db5af6f/97320630014194F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b216/6077820/b45a8635e125/97320630014194F7.jpg

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本文引用的文献

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The Forgotten Plague: Psychiatric Manifestations of Ebola, Zika, and Emerging Infectious Diseases.被遗忘的瘟疫：埃博拉、寨卡及新发传染病的精神症状
J Glob Infect Dis. 2017 Oct-Dec;9(4):151-156. doi: 10.4103/jgid.jgid_66_17.
2
Zika Virus: Immune Evasion Mechanisms, Currently Available Therapeutic Regimens, and Vaccines.寨卡病毒：免疫逃逸机制、当前可用的治疗方案及疫苗
Viral Immunol. 2017 Dec;30(10):682-690. doi: 10.1089/vim.2017.0046. Epub 2017 Oct 13.
3
Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil.
巴西萨尔瓦多都会区寨卡病毒爆发与吉兰-巴雷综合征发病率上升有关。
PLoS Negl Trop Dis. 2017 Aug 30;11(8):e0005869. doi: 10.1371/journal.pntd.0005869. eCollection 2017 Aug.
4
Zika Virus Persistently Infects and Is Basolaterally Released from Primary Human Brain Microvascular Endothelial Cells.寨卡病毒持续感染原代人脑微血管内皮细胞并从其基底外侧释放。
mBio. 2017 Jul 11;8(4):e00952-17. doi: 10.1128/mBio.00952-17.
5
Recent advances in understanding Epstein-Barr virus.爱泼斯坦-巴尔病毒研究的最新进展
F1000Res. 2017 Mar 29;6:386. doi: 10.12688/f1000research.10591.1. eCollection 2017.
6
Potential mechanisms of Zika-linked microcephaly.寨卡病毒相关小头畸形的潜在机制。
Wiley Interdiscip Rev Dev Biol. 2017 Jul;6(4). doi: 10.1002/wdev.273. Epub 2017 Apr 6.
7
Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells.生物信息学分析揭示了寨卡病毒感染的人类神经干细胞中独特转录组特征的表达。
Cell Biosci. 2016 Jun 10;6:42. doi: 10.1186/s13578-016-0110-x. eCollection 2016.
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Anticipating the Challenges of Zika Virus and the Incidence of Guillain-Barré Syndrome.应对寨卡病毒挑战及吉兰-巴雷综合征发病率问题
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JAMA Neurol. 2016 Jul 1;73(7):875-9. doi: 10.1001/jamaneurol.2016.0800.
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