酒类产品对醉酒小鼠的致醉作用评估。
Evaluation of intoxicating effects of liquor products on drunken mice.
作者信息
Wu Zhiqiang, Tian Xiaofei, He Songgui, Quan Lei, Wei Yunlu, Wu Zhenqiang
机构信息
School of Bioscience and Bioengineering , South China University of Technology , Guangzhou , 510006 , Guangdong , China . Email:
Guangdong Jiujiang Distillery Co. Ltd. , Foshan , 528203 , Guangdong , China.
出版信息
Medchemcomm. 2016 Oct 5;8(1):122-129. doi: 10.1039/c6md00491a. eCollection 2017 Jan 1.
Consumption of alcoholic beverages increases the risk of human health problems such as liver, heart and blood vessel diseases. In the present study, the concept of intoxicating degree (ID) is proposed as an index to demonstrate the degree of intoxicating activity for consuming liquor products. A mice model was designed for the evaluation of liquor product IDs. The intoxicating effects of liquor products were investigated by blood alcohol concentrations (BAC) and behaviour abilities of mice including righting reflex, running and forced-swim abilities. A linear regression model between comprehensive drunkenness degree (CD), calculated by integrating BAC and the behaviour abilities, and alcohol-feeding dosages (), was established (with > 0.9) with a slope factor of . The ratio of the values of liquor products to that of purified alcohol could be used to express the ID. For ID values less than 1, the liquor product would have a lower intoxicating effect when the same amount of alcohol content was consumed and .
饮用酒精饮料会增加人类出现健康问题的风险，如肝脏、心脏和血管疾病。在本研究中，提出了醉酒度（ID）的概念作为一个指标，以表明饮用酒类产品的醉酒活动程度。设计了一个小鼠模型来评估酒类产品的ID。通过血液酒精浓度（BAC）以及小鼠的行为能力（包括翻正反射、奔跑和强迫游泳能力）来研究酒类产品的醉酒效果。建立了一个综合醉酒度（CD）（通过整合BAC和行为能力计算得出）与酒精投喂剂量（）之间的线性回归模型（相关系数>0.9），斜率因子为 。酒类产品与纯酒精的 值之比可用于表示ID。对于ID值小于1的情况，当消耗相同量的酒精含量时，酒类产品的醉酒效果会较低。
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