Narawane N M, Bhatia S, Abraham P, Sanghani S, Sawant S S
Dept of Gastroenterology, KEM Hospital, Mumbai 400 012.
J Assoc Physicians India. 1998 Jun;46(6):510-3.
The amount of alcohol intake required for the development of liver disease has been determined in Western populations; corresponding figures in Indians, many of whom consume locally brewed liquors, are not known. We studied 328 patients from a public hospital in Mumbai who admitted to regular alcohol consumption, to determine the pattern of alcohol consumption and its relation to liver disease. Liver disease was more common in those who consumed illicitly-brewed as compared to licit liquor. Daily drinking, volume of consumption > 200 ml per day, and duration of drinking > 14 years were each significantly more common in those with liver disease. A cumulative intake of > 2000 ml. years, calculated as the product of volume (ml per day) and duration (years), was a reliable cut-off level for association with liver disease (sensitivity 65%, specificity 77%) and cirrhosis (sensitivity 70%, specificity 59%). The content of alcohol in these liquors, estimated in 23 samples, ranged from 23-36.1 g/100 ml, being lower in the illicit liquors. Thus, in Mumbai, alcoholic liver disease occurs more commonly with consumption of illicit liquor (despite its lower alcohol content); liver involvement appears earlier and with lower consumption levels than in the West.
西方人群中引发肝病所需的酒精摄入量已被确定；而对于许多饮用当地酿造酒类的印度人来说，相应的数据尚不明确。我们研究了孟买一家公立医院的328名承认有规律饮酒的患者，以确定饮酒模式及其与肝病的关系。与合法酒类相比，饮用非法酿造酒类的人患肝病更为常见。每日饮酒、每日饮酒量>200毫升以及饮酒时间>14年在肝病患者中各自更为常见。以饮酒量（毫升/天）与饮酒时间（年）的乘积计算，累积摄入量>2000毫升·年是与肝病（敏感性65%，特异性77%）和肝硬化（敏感性70%，特异性59%）相关的可靠临界值。对23个样本中这些酒类的酒精含量进行估算，其范围为23 - 36.1克/100毫升，非法酿造的酒类含量较低。因此，在孟买，酒精性肝病在饮用非法酿造酒类时更为常见（尽管其酒精含量较低）；与西方相比，肝脏受累出现得更早且饮酒量更低。
