一种以5,7-二氯-2-甲基-8-喹啉醇为配体的新型铁（III）配合物的合成及其抗肿瘤机制
Synthesis and antitumor mechanism of a new iron(iii) complex with 5,7-dichloro-2-methyl-8-quinolinol as ligands.
作者信息
Zou Bi-Qun, Qin Qi-Pin, Bai Yu-Xia, Cao Qian-Qian, Zhang Ye, Liu Yan-Cheng, Chen Zhen-Feng, Liang Hong
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , School of Chemistry & Pharmaceutical Sciences , Guangxi Normal University , Guilin , Guangxi 541004 , P. R. China . Email:
Department of Chemistry , Guilin Normal College , Guilin , Guangxi 541001 , P. R. China.
出版信息
Medchemcomm. 2017 Feb 1;8(3):633-639. doi: 10.1039/c6md00644b. eCollection 2017 Mar 1.
Abstract
A new iron(iii) complex with 5,7-dichloro-2-methyl-8-quinolinol (HClMQ) as ligands, , [Fe(ClMQ)Cl] (), was synthesized and evaluated for its anticancer activity. Compared to the HClMQ ligand, complex showed a higher cytotoxicity towards a series of tumor cell lines, including Hep-G2, BEL-7404, NCI-H460, A549, and T-24, with IC values in the range of 5.04-14.35 μM. Notably, the Hep-G2 cell line was the most sensitive to complex . Mechanistic studies indicated that complex is a telomerase inhibitor targeting c-myc G-quadruplex DNA and can trigger cell apoptosis inducing cell cycle arrest and DNA damage.
摘要
合成了一种以5,7-二氯-2-甲基-8-喹啉醇（HClMQ）为配体的新型铁（III）配合物[Fe(ClMQ)Cl]，并对其抗癌活性进行了评估。与HClMQ配体相比，配合物对一系列肿瘤细胞系，包括Hep-G2、BEL-7404、NCI-H460、A549和T-24，表现出更高的细胞毒性，IC值在5.04-14.35μM范围内。值得注意的是，Hep-G2细胞系对配合物最为敏感。机制研究表明，配合物是一种靶向c-myc G-四链体DNA的端粒酶抑制剂，可通过诱导细胞周期停滞和DNA损伤触发细胞凋亡。
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