Ahmad Irshad
Department of Mathematics and Natural Sciences , School of Arts and Sciences , American University of Ras Al Khaimah , Ras Al Khaimah , United Arab Emirates . Email:
Medchemcomm. 2017 Apr 7;8(5):871-885. doi: 10.1039/c7md00097a. eCollection 2017 May 1.
Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic drugs are available on the market, and several compounds are in different phases of clinical trials. Many studies suggest that these cytotoxic molecules are also associated with different types of adverse side effects; therefore researchers around the globe are involved in the development of more efficient and safer anticancer drugs. In recent years, quinazoline and its derivatives have been considered as a novel class of cancer chemotherapeutic agents that show promising activity against different tumors. The aim of this article is to comprehensively review and highlight the recent developments concerning the anticancer activity of quinazoline derivatives as well as offer perspectives on the development of novel quinazoline derivatives as anticancer agents in the near future.
癌症是全球人类死亡的主要原因之一。市场上有多种细胞毒性药物，还有几种化合物正处于不同阶段的临床试验中。许多研究表明，这些细胞毒性分子也与不同类型的不良副作用相关；因此，全球的研究人员都在致力于开发更高效、更安全的抗癌药物。近年来，喹唑啉及其衍生物被认为是一类新型的癌症化疗药物，对不同肿瘤显示出有前景的活性。本文的目的是全面综述并突出喹唑啉衍生物抗癌活性的最新进展，并对在不久的将来开发新型喹唑啉衍生物作为抗癌药物提供展望。
