Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.
Chem Biol Drug Des. 2022 Nov;100(5):639-655. doi: 10.1111/cbdd.14129. Epub 2022 Aug 12.
Quinazoline heterocycles are critical in the development of medications. Quinazoline derivatives have been intensively researched, providing a wide range of compounds with diverse biological roles. The quinazoline nucleus has garnered a lot of attention in medical chemistry in recent years. It was assumed to be a pharmacophore component in the development of physiologically interesting drugs. This review is an attempt to increase the potential of quinazoline by highlighting a wide range of advancements demonstrated by numerous derivatives of the quinazoline moiety, as well as focusing on diverse pharmacological actions of the quinazoline moiety. This review compiles recent studies on the quinazoline moiety described in the literature by researchers.
喹唑啉杂环在药物开发中至关重要。喹唑啉衍生物一直是研究的热点，提供了广泛的具有多种生物学作用的化合物。近年来，喹唑啉核在医学化学中受到了广泛关注。它被认为是开发具有生理意义的药物的药效团组成部分。本综述试图通过强调喹唑啉部分的许多衍生物所展示的广泛进展，并关注喹唑啉部分的多种药理学作用，来提高喹唑啉的潜力。本综述汇集了研究人员在文献中描述的喹唑啉部分的最新研究。
