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人B淋巴细胞在多克隆激活过程中表面IgD的丢失。

Loss of surface IgD by human B lymphocytes during polyclonal activation.

作者信息

Preudhomme J L

出版信息

Eur J Immunol. 1977 Mar;7(3):191-3. doi: 10.1002/eji.1830070316.

DOI:10.1002/eji.1830070316
PMID:301092
Abstract

Surface and cytoplasmic immunoglobulins were studied by direct immunofluorescence in pokeweed mitogen-stimulated cultures of human blood lymphocytes. The results compared to those of studies of unstimulated cultures and of fresh normal lymphocytes showed a striking decrease in surface IgD during terminal maturation of B lymphocytes into plasma cells. The number of cells which expressed IgG Fe receptor also decreased, although to a lesser extent.

摘要

通过直接免疫荧光法，对商陆有丝分裂原刺激的人血淋巴细胞培养物中的表面免疫球蛋白和细胞质免疫球蛋白进行了研究。与未刺激培养物和新鲜正常淋巴细胞的研究结果相比，结果显示，在B淋巴细胞向浆细胞的终末成熟过程中，表面IgD显著减少。表达IgG Fe受体的细胞数量也有所减少，尽管减少程度较小。

相似文献

1
Loss of surface IgD by human B lymphocytes during polyclonal activation.人B淋巴细胞在多克隆激活过程中表面IgD的丢失。
Eur J Immunol. 1977 Mar;7(3):191-3. doi: 10.1002/eji.1830070316.
2
Human peripheral blood B lymphocyte subpopulations: functional and phenotypic analysis of surface IgD positive and negative subsets.人类外周血B淋巴细胞亚群：表面IgD阳性和阴性亚群的功能及表型分析
J Immunol. 1986 Jan;136(1):83-92.
3
IgM- and IgD-bearing peripheral blood lymphocytes differentiate to IgM but not IgG or IgA immunoglobulin-secreting cells.携带IgM和IgD的外周血淋巴细胞分化为分泌IgM而非IgG或IgA免疫球蛋白的细胞。
Eur J Immunol. 1982 Jun;12(6):506-10. doi: 10.1002/eji.1830120611.
4
B- and T-lymphocyte markers on transformed lymphocytes from mitogen-stimulated cultures of normal and CLL lymphocytes and on tonsil blasts.来自正常淋巴细胞和慢性淋巴细胞白血病淋巴细胞的丝裂原刺激培养物以及扁桃体母细胞的转化淋巴细胞上的B和T淋巴细胞标志物。
Clin Exp Immunol. 1974 Aug;17(4):547-60.
5
Studies of surface immunoglobulins on human B lymphocytes. II. Characterization of a population of lymphocytes lacking surface immunoglobulins but carrying Fc receptor (SIg-Fc+ cell).人类B淋巴细胞表面免疫球蛋白的研究。II. 缺乏表面免疫球蛋白但携带Fc受体的淋巴细胞群体的特征（表面免疫球蛋白阴性-Fc阳性细胞）
J Immunol. 1976 Nov;117(5 Pt.2):1781-7.
6
Activation of B cells in vivo by a Fab/Fc fragment of a monoclonal anti-IgD antibody requires an interaction between the antibody fragment and a cellular IgG Fc receptor.单克隆抗IgD抗体的Fab/Fc片段在体内激活B细胞需要该抗体片段与细胞IgG Fc受体之间的相互作用。
J Immunol. 1988 May 1;140(9):2919-24.
7
Multiple myeloma with monoclonal IgG and IgD of lambda type exhibiting, under treatment, a shift from mainly IgG to mainly IgD.伴有λ型单克隆IgG和IgD的多发性骨髓瘤，在治疗过程中，呈现出从主要为IgG向主要为IgD的转变。
Immunology. 1985 May;55(1):45-57.
8
Human B cell differentiation. III. Enhancing effect of monoclonal anti-immunoglobulin D antibody on pokeweed mitogen-induced plasma cell differentiation.人类B细胞分化。III. 单克隆抗免疫球蛋白D抗体对商陆丝裂原诱导的浆细胞分化的增强作用。
J Immunol. 1982 Dec;129(6):2490-5.
9
Hyper immunoglobulin M immunodeficiency. (Dysgammaglobulinemia). Presence of immunoglobulin M-secreting plasmacytoid cells in peripheral blood and failure of immunoglobulin M-immunoglobulin G switch in B-cell differentiation.高免疫球蛋白M免疫缺陷（异常丙种球蛋白血症）。外周血中存在分泌免疫球蛋白M的浆细胞样细胞，且B细胞分化过程中免疫球蛋白M向免疫球蛋白G的转换失败。
J Clin Invest. 1979 Aug;64(2):385-91. doi: 10.1172/JCI109473.
10
Human peripheral blood B cell subpopulations: surface IgD+ cells respond to pokeweed mitogen with plasma cell differentiation.人类外周血B细胞亚群：表面IgD+细胞对商陆丝裂原产生反应并分化为浆细胞。
Clin Exp Immunol. 1986 Apr;64(1):150-7.

引用本文的文献

1
Deoxyspergualin preferentially inhibits the growth and maturation of anti-CD40-activated surface IgD+ B lymphocytes.去氧精胍菌素优先抑制抗CD40激活的表面IgD+B淋巴细胞的生长和成熟。
Clin Exp Immunol. 1998 Jun;112(3):495-500. doi: 10.1046/j.1365-2249.1998.00602.x.
2
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms.IgD的表达可能同时利用DNA重排和RNA剪接机制。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1800-4. doi: 10.1073/pnas.78.3.1800.
3
Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy.
丙种球蛋白治疗诱导的商陆有丝分裂原刺激的T和B淋巴细胞反应功能障碍。
J Clin Invest. 1981 Mar;67(3):867-77. doi: 10.1172/jci110104.