Oyedemi Blessing O, Oyedemi Sunday O, Chibuzor Johnson V, Ijeh Ifeoma I, Coopoosamy Roger M, Aiyegoro Ayobami O
Department of Plant Science and Biotechnology, Michael Okpara University of Agriculture, Umudike, Nigeria.
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.
ScientificWorldJournal. 2018 Jul 4;2018:4757458. doi: 10.1155/2018/4757458. eCollection 2018.
Oral and skin infections contribute significantly to the global health challenges responsible for the current trend of increased morbidity and premature death. The purpose of this study was to document medicinal plants used in the management of oral and skin infections in Ebem-Ohafia Local Government Area (LGA), Abia State, and to characterize the antioxidant and antibacterial activity. The thin layer chromatography (TLC) profiling of ten of the selected folklore medicine was carried out using a various solvent system of different polarity index. The antioxidant capacity of the plant extracts was evaluated using chemical-based methods, and its antibacterial effect was investigated using disc diffusion and microdilution methods. Sixty-one plant species belonging to 26 families were discovered, and the most frequently cited species are Euphorbiaceae (18.03%), Fabaceae (11.47%), and Asteraceae (11.47%). All the plant extracts showed a promising free radical scavenging activity and efficient ferric reducing antioxidant power in a concentration-dependent manner possibly due to their richness in polyphenol with TLC profiling showing maximum three bands of phytochemicals. Also, the plant extracts exhibited a mild to weak antibacterial activity against our panel of bacterial strains having MIC values ranging from 256 to > 512 g/ mL reflected in their zone of inhibition at 10 g/disc. The data obtained for (BN), (EI), (CA), (CO), and (AH) extracts substantiate the traditional use of these herbal remedies in the region and open the possibility for the development of cheaper and affordable drugs in the treatment of oral and skin infections. Further studies are needed to identify active ingredient with strong antibacterial and antioxidant capacities along with their molecular mechanisms.
口腔和皮肤感染对全球健康构成重大挑战，导致当前发病率上升和过早死亡的趋势。本研究的目的是记录阿比亚州埃贝姆 - 奥哈菲亚地方政府辖区用于治疗口腔和皮肤感染的药用植物，并对其抗氧化和抗菌活性进行表征。使用不同极性指数的各种溶剂系统对十种选定的民间药物进行薄层色谱（TLC）分析。采用基于化学的方法评估植物提取物的抗氧化能力，并使用纸片扩散法和微量稀释法研究其抗菌效果。发现了属于26个科的61种植物，其中被提及频率最高的科是大戟科（18.03%）、豆科（11.47%）和菊科（11.47%）。所有植物提取物均表现出良好的自由基清除活性和高效的铁还原抗氧化能力，且呈浓度依赖性，这可能是由于它们富含多酚，TLC分析显示最多有三条植物化学物质带。此外，植物提取物对我们的一组细菌菌株表现出轻度至弱的抗菌活性，其MIC值范围为256至>512 μg/mL，在10 μg/纸片时其抑菌圈即反映出这一点。从（BN）、（EI）、（CA）、（CO）和（AH）提取物获得的数据证实了该地区这些草药疗法的传统用途，并为开发治疗口腔和皮肤感染的更便宜且可负担得起的药物提供了可能性。需要进一步研究以确定具有强大抗菌和抗氧化能力的活性成分及其分子机制。
