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尼日利亚东南部传统治疗师使用的一些抗糖尿病植物的α-淀粉酶抑制作用和抗氧化能力

Alpha-Amylase Inhibition and Antioxidative Capacity of Some Antidiabetic Plants Used by the Traditional Healers in Southeastern Nigeria.

作者信息

Oyedemi Sunday O, Oyedemi Blessing O, Ijeh Ifeoma I, Ohanyerem Princemartins E, Coopoosamy Roger M, Aiyegoro Olayinka A

机构信息

Department of Nature Conservation and Ethnobotany, Mangosuthu University of Technology P.O. Box 12363, Jacobs, Durban 4026, South Africa.

Department of Plant Science and Biotechnology, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.

出版信息

ScientificWorldJournal. 2017;2017:3592491. doi: 10.1155/2017/3592491. Epub 2017 Mar 6.

DOI:10.1155/2017/3592491
PMID:28367491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5358441/
Abstract

Oxidative stress plays a significant role in the pathogenesis of metabolic syndrome including diabetes mellitus (DM). The inhibition of alpha-amylase is an important therapeutic target in the regulation of postprandial increase of blood glucose in diabetic patients. The present study investigated the alpha-amylase inhibitory and antioxidant potential of selected herbal drugs used in the treatment of DM by the traditional healers in Isiala Mbano and Ikwuano regions of southeastern Nigeria. Antioxidant activity was evaluated in terms of free radical scavenging, reducing power, and total phenolic (TPC) and flavonoid content (TFC) in consonance with the TLC profiling. The results showed that methanol crude extracts from (AO) and (CP) recorded higher TPC and TFC, potent free radical scavenging, and efficient reducing power (RP) as compared with other plant samples. All the plant extracts exhibited a relative alpha-amylase inhibition apart from (SH) extract with a negative effect. We discovered a mild to weak correlation between alpha-amylase inhibition or antioxidative capacity and the total phenol or flavonoid content. At least in part, the results obtained in this work support the traditional use of certain plant species in the treatment of patients with DM.

摘要

氧化应激在包括糖尿病（DM）在内的代谢综合征发病机制中起重要作用。抑制α-淀粉酶是调节糖尿病患者餐后血糖升高的重要治疗靶点。本研究调查了尼日利亚东南部伊西亚拉·姆巴诺和伊夸诺地区传统治疗师用于治疗糖尿病的特定草药的α-淀粉酶抑制和抗氧化潜力。根据薄层色谱分析，从自由基清除、还原能力以及总酚（TPC）和类黄酮含量（TFC）方面评估抗氧化活性。结果表明，与其他植物样品相比，来自[植物名称AO]和[植物名称CP]的甲醇粗提物具有更高的TPC和TFC含量，并具有强大的自由基清除能力和高效的还原能力（RP）。除了具有负面影响的[植物名称SH]提取物外，所有植物提取物均表现出相对的α-淀粉酶抑制作用。我们发现α-淀粉酶抑制或抗氧化能力与总酚或类黄酮含量之间存在轻度至弱的相关性。至少在一定程度上，本研究所得结果支持了某些植物物种在治疗糖尿病患者方面的传统用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/5090c96030be/TSWJ2017-3592491.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/dc602fead50d/TSWJ2017-3592491.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/eaa8283b099f/TSWJ2017-3592491.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/bb12ee8a9344/TSWJ2017-3592491.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/a4950569629c/TSWJ2017-3592491.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/785fdc5c4a48/TSWJ2017-3592491.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/5090c96030be/TSWJ2017-3592491.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/dc602fead50d/TSWJ2017-3592491.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/eaa8283b099f/TSWJ2017-3592491.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/bb12ee8a9344/TSWJ2017-3592491.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/a4950569629c/TSWJ2017-3592491.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/785fdc5c4a48/TSWJ2017-3592491.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2b/5358441/5090c96030be/TSWJ2017-3592491.006.jpg

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2
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J Ethnopharmacol. 2014 Sep 11;155(2):857-924. doi: 10.1016/j.jep.2014.05.055. Epub 2014 Jun 12.
3
Antioxidant and neuroprotective activities of Hyptis suaveolens (L.) Poit. against oxidative stress-induced neurotoxicity.
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Foods. 2025 Apr 11;14(8):1331. doi: 10.3390/foods14081331.
4
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5
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Toxics. 2023 Jun 27;11(7):561. doi: 10.3390/toxics11070561.
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Cell Mol Neurobiol. 2014 Apr;34(3):323-31. doi: 10.1007/s10571-013-0016-7. Epub 2014 Jan 14.
4
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Iran J Pharm Res. 2012 Summer;11(3):913-23.
5
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Phytomedicine. 1996 Sep;3(2):203-9. doi: 10.1016/S0944-7113(96)80037-7.
6
Antioxidant ability and total phenolic content of aqueous leaf extract of Stevia rebaudiana Bert.甜叶菊叶水提取物的抗氧化能力和总酚含量
Exp Toxicol Pathol. 2012 Nov;64(7-8):807-11. doi: 10.1016/j.etp.2011.02.002. Epub 2011 Mar 5.
7
Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats, India.印度西高止山脉蒂鲁内尔维利丘陵地带卡尼部落常用药用植物的民族植物学调查。
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8
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9
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10
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Biochemistry. 2010 Jan 26;49(3):443-51. doi: 10.1021/bi9016457.