非肌层浸润性膀胱癌患者的总液体摄入量与复发风险：一项前瞻性队列研究。
Total Fluid Intake and the Risk of Recurrence in Patients With Non-Muscle Invasive Bladder Cancer: A Prospective Cohort Study.
作者信息
Jochems Sylvia H J, van Osch Frits H M, Reulen Raoul C, van Hensbergen Mitch, Nekeman Duncan, Pirrie Sarah J, Wesselius Anke, van Schooten Frederik J, James Nicholas D, Wallace D Michael A, Bryan Richard T, Cheng K K, Zeegers Maurice P
机构信息
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
School for Nutrition and Translational Research in Metabolism, Maastricht University, The Netherlands.
出版信息
Bladder Cancer. 2018 Jul 30;4(3):303-310. doi: 10.3233/BLC-180172.
OBJECTIVES
To investigate the role of fluid intake from beverages before and after a diagnosis of bladder cancer in relation to the risk of developing bladder cancer recurrence.
STUDY DESIGN
Prospective cohort study.
METHODS
716 patients with non-muscle invasive bladder cancer (NMIBC), who received transurethral resection of a primary bladder tumour (TURBT) and completed self-administrated questionnaires on usual fluid intake from beverages at time of diagnosis (over the year before diagnosis) and during follow-up (over the year after diagnosis), were included. Multivariable Cox regression was used to calculate hazard ratios and 95% confidence intervals of developing recurrent bladder cancer in relation to the intake of total fluid, total alcohol, and individual beverages.
RESULTS
During 2,025 person-years of follow-up, 238 (33%) of the included 716 NMIBC patients developed one or more recurrences of bladder cancer. Total fluid intake before diagnosis was not associated with a first recurrence of bladder cancer when comparing the highest and lowest intake group (HR = 0.98, 95% C.I. 0.70-1.38, = 0.91). Comparable results were obtained for total fluid intake pre-diagnosis and the risk of developing multiple recurrences of bladder cancer (HR = 1.01, 95% C.I. 0.87-1.19, = 0.85). A total of 379 of the 716 patients reported on usual fluid intake within 1 year of diagnosis. No significant associations between total fluid intake 1 year after diagnosis and a first recurrence of bladder cancer were found when comparing the highest and lowest intake group (HR = 0.91; 95% C.I. 0.60-1.37, = 0.65) or with multiple recurrences of bladder cancer (HR = 1.06; 95% C.I. 0.89-1.26, = 0.54). In addition, total alcohol intake and individual beverages were not associated with bladder cancer recurrence.
CONCLUSIONS
The results indicate that an individual's fluid intake from beverages is unlikely to have an important role in bladder cancer recurrence.
目的
探讨膀胱癌诊断前后从饮料中摄入液体与膀胱癌复发风险之间的关系。
研究设计
前瞻性队列研究。
方法
纳入716例非肌层浸润性膀胱癌（NMIBC）患者，这些患者接受了原发性膀胱肿瘤经尿道切除术（TURBT），并完成了关于诊断时（诊断前一年）和随访期间（诊断后一年）从饮料中通常液体摄入量的自填问卷。多变量Cox回归用于计算与总液体、总酒精和各种饮料摄入量相关的膀胱癌复发风险比和95%置信区间。
结果
在2025人年的随访期间，716例纳入的NMIBC患者中有238例（33%）出现了一次或多次膀胱癌复发。比较最高和最低摄入量组时，诊断前的总液体摄入量与膀胱癌首次复发无关（风险比=0.98，95%置信区间0.70 - 1.38，P = 0.91）。诊断前总液体摄入量与膀胱癌多次复发风险的结果相似（风险比=1.01，95%置信区间0.87 - 1.19，P = 0.85）。716例患者中有379例报告了诊断后1年内的通常液体摄入量。比较最高和最低摄入量组时，未发现诊断后1年的总液体摄入量与膀胱癌首次复发之间存在显著关联（风险比=0.91；95%置信区间0.60 - 1.37，P = 0.65），与膀胱癌多次复发也无关联（风险比=1.06；95%置信区间0.89 - 1.26，P = 0.54）。此外，总酒精摄入量和各种饮料与膀胱癌复发无关。
结论
结果表明，个体从饮料中摄入的液体不太可能在膀胱癌复发中起重要作用。
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