圆叶牵牛粗水提取物的神经肌肉阻断活性。

Neuromuscular blocking activity of a crude aqueous extract of Ipomoea fistulosa.

作者信息

Abdelhadi A A, Elkheir Y M, Hassan T, Mustafa A A

出版信息

Clin Exp Pharmacol Physiol. 1986 Feb;13(2):169-71. doi: 10.1111/j.1440-1681.1986.tb00332.x.

DOI:10.1111/j.1440-1681.1986.tb00332.x

Abstract

The rat phrenic nerve hemidiaphragm and chick biventer-cervicis preparations were used to investigate the effect of a crude aqueous extract of Ipomoea fistulosa. Electrically-induced skeletal muscle twitches of the hemidiaphragm were blocked by the extract and by tubocurarine. The anticholinesterase, physostigmine, intensified the blockade by the extract. The extract produced contracture of the chick biventer-cervicis preparation. It is suggested that the extract possesses neuromuscular blocking activity of a depolarizing nature.

摘要

采用大鼠膈神经 - 半膈肌和鸡二腹肌 - 颈肌标本，研究了管花薯的粗水提取物的作用。该提取物和筒箭毒碱均可阻断电刺激引起的半膈肌骨骼肌抽搐。抗胆碱酯酶药毒扁豆碱可增强该提取物的阻断作用。该提取物可使鸡二腹肌 - 颈肌标本发生挛缩。提示该提取物具有去极化性质的神经肌肉阻断活性。