Sugiura M, Hashimoto A, Shizawa M, Tsukada M, Maruyama S, Ishido T, Kasahara T, Hirata Y
Diabetes Res. 1986 Mar;3(3):111-4.
A sensitive assay method for pituitary cell antibodies (PitCA) was established by a biotin/avidin system using rat pituitary. Results in 24 cases out of 81 insulin-dependent diabetic patients and 10 cases of 21 adrenocorticotropic hormone (ACTH) deficient patients were positive for autoantibodies to anterior pituitary cell cytoplasm. PitCA observed in the sera of insulin-dependent diabetic patients were suspected of being pituitary specific and independent with islet cell antibodies (ICA) and islet cell surface antibodies (ICSA). In the sera of ACTH deficient patients, PitCA were frequently absorbed with liver acetone powder. Populations of insulin-dependent diabetes mellitus (IDDM) are almost equal in males and females. A total of 16 cases out of 21 ACTH deficient patients were female. These results suggest that heterogenous PitCA are involved in the sera of those patients with IDDM and ACTH deficiency.
采用生物素/抗生物素蛋白系统，利用大鼠垂体建立了一种检测垂体细胞抗体（PitCA）的灵敏方法。81例胰岛素依赖型糖尿病患者中有24例，21例促肾上腺皮质激素（ACTH）缺乏患者中有10例，其抗垂体前叶细胞质自身抗体检测呈阳性。在胰岛素依赖型糖尿病患者血清中观察到的PitCA被怀疑是垂体特异性的，且与胰岛细胞抗体（ICA）和胰岛细胞表面抗体（ICSA）无关。在ACTH缺乏患者的血清中，PitCA常被肝丙酮粉吸收。胰岛素依赖型糖尿病（IDDM）患者的男女比例几乎相等。21例ACTH缺乏患者中共有16例为女性。这些结果表明，异质性PitCA存在于IDDM和ACTH缺乏患者的血清中。
