Department of Public Health, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Laboratory Genetic Metabolic Diseases, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
J Clin Endocrinol Metab. 2018 Oct 1;103(10):3783-3791. doi: 10.1210/jc.2018-00809.
Type 2 diabetes and cardiovascular disease occur more frequently and at a younger age in South-Asians than Europeans. This may be related to differences in regulation of the fatty acid metabolism during aging. We compared age-related acylcarnitine and amino acid concentrations in Dutch and South-Asian Surinamese study participants.
We measured types of acylcarnitine and amino acid concentrations in plasma (by tandem mass spectrometry) in a random subsample of 350 Dutch and 350 South-Asian Surinamese origin participants of the Healthy Life in an Urban Setting study (Amsterdam, Netherlands). We derived principal components (PCs) from the metabolites. Linear regression was used to assess differences in PCs and individual metabolite concentrations, and their age trends between the groups by sex. We adjusted for body mass index and intake of fat and total energy.
Mean age was 44.8 (SD, 13.3) years. Amino acid concentrations were higher among South-Asian Surinamese women compared with Dutch women; acylcarnitine and amino acid levels were higher among South-Asian Surinamese men than Dutch men. Metabolite levels increased similarly with age in both ethnic groups. Results remained similar after adjustment.
Ethnic differences in metabolite concentrations suggest that fatty acid and amino acid metabolism are more dysregulated among South-Asian Surinamese compared with Dutch from a young age. During adulthood, metabolites increase similarly in both ethnic groups.
2 型糖尿病和心血管疾病在南亚人群中的发生频率和发病年龄均早于欧洲人群。这可能与脂肪酸代谢在衰老过程中的调节差异有关。我们比较了荷兰和南亚苏里南裔研究参与者的年龄相关酰基肉碱和氨基酸浓度。
我们在健康生活城市环境研究（荷兰阿姆斯特丹）的一个随机亚组中测量了 350 名荷兰裔和 350 名南亚苏里南裔参与者的血浆中酰基肉碱和氨基酸的类型浓度（通过串联质谱法）。我们从代谢物中得出主成分（PC）。线性回归用于评估组间性别差异的 PC 和个体代谢物浓度及其年龄趋势，并进行了体重指数和脂肪及总能量摄入的调整。
平均年龄为 44.8（标准差，13.3）岁。与荷兰女性相比，南亚苏里南裔女性的氨基酸浓度更高；与荷兰男性相比，南亚苏里南裔男性的酰基肉碱和氨基酸水平更高。两组的代谢物水平随年龄增长相似。调整后结果仍然相似。
代谢物浓度的种族差异表明，与荷兰人相比，南亚苏里南裔人群的脂肪酸和氨基酸代谢从年轻时就更加失调。在成年期，两组的代谢物水平增长相似。
