硝普钠对犬胰腺外分泌及胰腺中环核苷酸浓度的影响。

Effects of nitroprusside on pancreatic exocrine secretion and cyclic nucleotide concentration in the dog pancreas.

作者信息

Iwatsuki K, Iijima F, Yamagishi F, Chiba S

出版信息

Eur J Pharmacol. 1986 Apr 16;123(2):307-9. doi: 10.1016/0014-2999(86)90674-6.

Abstract

The effects of intravenous injection of nitroprusside on pancreatic exocrine secretion and on pancreatic cyclic AMP and cyclic GMP concentrations of mongrel dogs were investigated. Nitroprusside (10-100 micrograms/kg) increased the exocrine secretion together with the increase in cyclic GMP concentration dose dependently but did not affect the cyclic AMP concentration. These results suggest that nitroprusside causes exocrine secretion from the dog pancreas mediated through an increase of intracellular cyclic GMP concentration.

摘要

研究了静脉注射硝普钠对杂种犬胰腺外分泌及胰腺环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）浓度的影响。硝普钠（10 - 100微克/千克）剂量依赖性地增加外分泌，同时使cGMP浓度升高，但对cAMP浓度无影响。这些结果表明，硝普钠通过增加细胞内cGMP浓度介导犬胰腺的外分泌。