Iwatsuki K, Horiuchi A, Yamagishi F, Chiba S
Arch Int Pharmacodyn Ther. 1987 Apr;286(2):320-8.
The effects of forskolin on the secretion of pancreatic juice and on the intracellular levels of cyclic nucleotides were investigated in preparations of the isolated and blood-perfused dog pancreas. Forskolin (3-100 micrograms) injected intra-arterially caused a dose-dependent increase in the secretion of pancreatic juice. The concentration of bicarbonate in the pancreatic juice induced by forskolin was increased. However, protein concentration was decreased. Forskolin-induced secretion was not modified by pretreatment with atropine, phentolamine, propranolol, cimetidine, sulpiride and verapamil. Forskolin (10-30 micrograms) significantly increased cyclic AMP concentration in the pancreatic tissue before the onset of the pancreatic secretion. On the other hand, cyclic GMP concentration was not influenced significantly throughout 30 min after the administration of forskolin. From these results, it is concluded that forskolin may produce an increase in pancreatic secretion mediated through an increase of intracellular cyclic AMP concentration.
在离体并经血液灌流的犬胰腺制备物中，研究了福斯高林对胰液分泌及细胞内环核苷酸水平的影响。动脉内注射福斯高林（3 - 100微克）可引起胰液分泌呈剂量依赖性增加。福斯高林诱导的胰液中碳酸氢盐浓度升高。然而，蛋白质浓度降低。用阿托品、酚妥拉明、普萘洛尔、西咪替丁、舒必利和维拉帕米预处理后，福斯高林诱导的分泌未发生改变。在胰液分泌开始前，福斯高林（10 - 30微克）显著增加了胰腺组织中环磷酸腺苷（cAMP）的浓度。另一方面，在给予福斯高林后的30分钟内，环磷酸鸟苷（cGMP）浓度未受到显著影响。从这些结果得出结论，福斯高林可能通过增加细胞内环磷酸腺苷浓度介导胰液分泌增加。
