Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China; Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Biomed Pharmacother. 2018 Nov;107:615-624. doi: 10.1016/j.biopha.2018.07.147. Epub 2018 Aug 14.
Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid with immense therapeutic potential. Lycorine is active in a very low concentration and with high specificity against a number of cancers both in vivo and in vitro and against various drug-resistant cancer cells. This review summarized the therapeutic effect and the anticancer mechanisms of lycorine. At the same time, we have discussed the pharmacology and comparative structure-activity relationship for the anticancer activity of this compound. The researches outlined in this paper serve as a foundation to explain lycorine as an important lead compound for new generation anticancer drug design and provide the principle for the development of biological strategies to utilize lycorine in the treatment of cancers.
自然是新药发现的最丰富来源。石蒜碱是一种具有巨大治疗潜力的天然生物碱。石蒜碱在体内和体外对多种癌症和各种耐药癌细胞具有非常低的浓度和高度的特异性，具有活性。本综述总结了石蒜碱的治疗效果和抗癌机制。同时，我们还讨论了该化合物抗癌活性的药理学和比较结构-活性关系。本文概述的研究为将石蒜碱解释为新一代抗癌药物设计的重要先导化合物提供了基础，并为利用石蒜碱治疗癌症的生物策略的发展提供了原理。
