Cao ZhiFei, Yang Ping, Zhou QuanSheng
Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University; Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University, Suzhou, 215006 China.
Sci China Chem. 2013;56(10):1382-1391. doi: 10.1007/s11426-013-4967-9. Epub 2013 Aug 24.
Lycorine is the major active component from the amaryllidaceae family plant , a represent traditional Chinese medicinal herb, and is one of the typical alkaloids with pyrrolophenanthridine nucleus core. Lycorine has drawn great interest in medicinal field due to its divergent chemical structures and multiple biological functions, as well as pharmacological effects on various diseases. Accumulated evidence shows that lycorine not only possesses strong pharmacological effects on many diseases, including anti-leukemia, anti-tumor, anti-angiogenesis, anti-virus, anti-bacteria, anti-inflammation, and antimalaria, but also exerts many other biological functions, such as inhibition of acetylcholinesterase and topoisomerase, suppression of ascorbic acid biosynthesis, and control of circadian period length. Notably, lycorine exhibits its numerous pharmacological effects on various diseases with very low toxicity and mild side effects. The divergent chemical structures, multiple biological functions, and very low toxicity of lycorine imply that the agent is a potential drug candidate that warrants for further preclinical and clinic investigation.
石蒜碱是石蒜科植物中的主要活性成分，石蒜科植物是一种典型的传统中草药，石蒜碱是具有吡咯并菲啶核核心的典型生物碱之一。由于其不同的化学结构、多种生物学功能以及对各种疾病的药理作用，石蒜碱在医学领域引起了极大的关注。越来越多的证据表明，石蒜碱不仅对许多疾病具有强大的药理作用，包括抗白血病、抗肿瘤、抗血管生成、抗病毒、抗菌、抗炎和抗疟疾，还具有许多其他生物学功能，如抑制乙酰胆碱酯酶和拓扑异构酶、抑制抗坏血酸生物合成以及控制昼夜节律周期长度。值得注意的是，石蒜碱对各种疾病表现出众多药理作用，且毒性极低，副作用轻微。石蒜碱不同的化学结构、多种生物学功能以及极低的毒性表明，该药物是一种有潜力的候选药物，值得进一步进行临床前和临床研究。
