Okajima T, Hertting G
Horm Metab Res. 1986 Apr;18(4):281-2. doi: 10.1055/s-2007-1012296.
AVP (10(-7) M) induced ACTH as well as PGE2 release from rat anterior pituitary quarters. Inhibitors of P-450 monooxygenase, metyrapone (10 mM) and piperonyl butoxide (1 mM and 10 mM) attenuated the ACTH and PGE2 response to AVP. 7,8-benzoflavon (10 mM) which inhibits 3-methylchloranthrene inducible form of P-450 isoenzymes showed no inhibition of AVP-induced ACTH secretion. The decrease in ACTH response to AVP was still observed following the inhibition of prostaglandin synthesis by indomethacin. These results suggest that cytochrome P-450 monoocygenase systems are involved in the process of AVP-induced ACTH secretion, 3-methylchloranthrene inducible form of P-450 isoenzymes do not seem to be involved in this process.
血管加压素（10⁻⁷ M）可诱导大鼠垂体前叶释放促肾上腺皮质激素（ACTH）以及前列腺素E2（PGE2）。P-450单加氧酶抑制剂美替拉酮（10 mM）和胡椒基丁醚（1 mM和10 mM）减弱了ACTH和PGE2对血管加压素的反应。抑制3-甲基胆蒽诱导型P-450同工酶的7,8-苯并黄酮（10 mM）对血管加压素诱导的促肾上腺皮质激素分泌无抑制作用。在吲哚美辛抑制前列腺素合成后，仍观察到ACTH对血管加压素反应的降低。这些结果表明，细胞色素P-450单加氧酶系统参与了血管加压素诱导促肾上腺皮质激素分泌的过程，3-甲基胆蒽诱导型P-450同工酶似乎不参与此过程。
