Diakonis Vasilios F, Anagnostopoulos Apostolos G, Moutsiopoulou Angeliki, Yesilirmak Nilufer, Cabot Florence, Waren Daniel P, O'Brien Terrence P, Yoo Sonia H, Weinstock Robert J, Donaldson Kendall E
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
The Eye Institute of West Florida, Largo, FL, USA.
J Ophthalmol. 2018 Jul 10;2018:1891249. doi: 10.1155/2018/1891249. eCollection 2018.
To assess aqueous humor concentration of prostaglandin E (PGE) after capsulotomy creation using a femtosecond laser (FLAC) in patients pretreated with short-term topical ketorolac versus patients without pretreatment.
This prospective study comprised consecutive patients scheduled to undergo cataract surgery using a femtosecond laser platform to perform only capsulotomies. An identical protocol for preoperative mydriasis was used for all the eyes included in the study, while aqueous humor was extracted from the anterior chamber of all patients immediately after the initial side port incision. ELISA was performed to quantify aqueous humor PGE. The patients were divided into 2 groups; in group 1, the patients received short-term topical ketorolac preoperatively, while the patients in group 2 did not receive NSAID pretreatment.
Twenty eyes of 20 patients were included in the study (10 eyes in each group). Mean concentration of aqueous humor PGE after FLAC was 392.16 ± 162.00 pg/ml and 622.63 ± 331.84 pg/ml for groups 1 and 2, respectively. A statistically significant difference in aqueous humor PGE concentration between the two groups ( < 0.05) was demonstrated, with the eyes that received ketorolac pretreatment demonstrating a lower concentration of PGE.
Short-term topical use of ketorolac prior to FLAC seems to prevent excessive release of PGE in the anterior chamber of the eyes that received NSAID pretreatment when compared to the eyes that did not receive NSAIDs preoperatively.
评估在接受短期局部使用酮咯酸预处理的患者与未接受预处理的患者中，使用飞秒激光进行囊切开术后房水中前列腺素E（PGE）的浓度。
这项前瞻性研究纳入了连续的计划使用飞秒激光平台仅进行囊切开术的白内障手术患者。研究中纳入的所有眼睛均采用相同的术前散瞳方案，所有患者在最初的侧切口后立即从前房中抽取房水。采用酶联免疫吸附测定法（ELISA）定量房水中的PGE。患者分为2组；第1组患者术前接受短期局部使用酮咯酸，而第2组患者未接受非甾体抗炎药预处理。
20例患者的20只眼纳入研究（每组10只眼）。飞秒激光术后第1组和第2组房水中PGE的平均浓度分别为392.16±162.00 pg/ml和622.63±331.84 pg/ml。两组房水中PGE浓度存在统计学显著差异（<0.05），接受酮咯酸预处理的眼睛PGE浓度较低。
与术前未接受非甾体抗炎药的眼睛相比，飞秒激光术前短期局部使用酮咯酸似乎可防止接受非甾体抗炎药预处理的眼睛前房中PGE过度释放。
