From the Department of Ophthalmology (Jun), Keimyung University School of Medicine, and Nune Eye Hospital (Lim), Daegu, the Catholic Institute for Visual Science (Yoo, Joo), and the Department of Ophthalmology and Visual Science (Joo), Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea.
From the Department of Ophthalmology (Jun), Keimyung University School of Medicine, and Nune Eye Hospital (Lim), Daegu, the Catholic Institute for Visual Science (Yoo, Joo), and the Department of Ophthalmology and Visual Science (Joo), Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea.
J Cataract Refract Surg. 2017 Apr;43(4):492-497. doi: 10.1016/j.jcrs.2017.01.011.
To determine the effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E (PGE) release during femtosecond laser-assisted cataract surgery.
Seoul St. Mary's Hospital, Seoul, Korea.
Prospective case series.
The study comprised the following 3 groups: conventional cataract surgery without topical NSAIDs (conventional group); femtosecond laser-assisted cataract surgery with preoperative topical ketorolac tromethamine 0.45% (femtosecond NSAID group), and femtosecond laser-assisted cataract surgery without topical NSAIDs (femtosecond no-NSAID group). To measure the aqueous humor PGE concentration, a 100 μL aqueous humor sample was collected from the anterior chamber after femtosecond laser pretreatment. The PGE concentration was measured using an enzyme immunoassay.
Topical ketorolac tromethamine 0.45% led to a significant reduction in intraoperative miosis in the femtosecond NSAID group compared with the femtosecond no-NSAID group (P < .001). Absolute and relative reductions in pupil area in the femtosecond NSAID group were significantly lower than in the femtosecond no-NSAID group (P = .019 and P = .007, respectively). The mean aqueous humor PGE concentrations were 893.60 pg/mL ± 843.10 (SD) in the conventional group, 1911.43 ± 1178.63 pg/mL in the femtosecond NSAID group, and 743.63 ± 927.46 pg/mL in the femtosecond no-NSAID group (P < .001, conventional versus femtosecond NSAID and femtosecond NSAID versus femtosecond no NSAID; P > .05, conventional versus femtosecond NSAID).
Preoperative topical ketorolac tromethamine 0.45% reduced miosis induced by femtosecond laser pretreatment and inhibited aqueous humor PGE elevation.
研究 0.45%酒石酸溴莫尼定滴眼剂对飞秒激光辅助白内障手术中瞳孔缩小和前列腺素 E (PGE) 释放的影响。
韩国首尔圣玛丽医院。
前瞻性病例系列。
本研究包括以下 3 组：未使用局部非甾体抗炎药的常规白内障手术（常规组）；飞秒激光辅助白内障手术术前使用 0.45%酒石酸溴莫尼定滴眼剂（飞秒 NSAID 组）和未使用局部非甾体抗炎药的飞秒激光辅助白内障手术（飞秒无 NSAID 组）。在飞秒激光预处理前，从前房采集 100 μL 房水样本，以测量房水 PGE 浓度。采用酶联免疫吸附法测量 PGE 浓度。
与飞秒无 NSAID 组相比，飞秒 NSAID 组中 0.45%酒石酸溴莫尼定滴眼剂滴眼可显著减少术中瞳孔缩小（P<.001）。飞秒 NSAID 组瞳孔面积的绝对和相对减少均明显低于飞秒无 NSAID 组（P=.019 和 P=.007）。常规组平均房水 PGE 浓度为 893.60 pg/mL±843.10（SD），飞秒 NSAID 组为 1911.43±1178.63 pg/mL，飞秒无 NSAID 组为 743.63±927.46 pg/mL（P<.001，常规组与飞秒 NSAID 组和飞秒 NSAID 组与飞秒无 NSAID 组；P>.05，常规组与飞秒 NSAID 组）。
术前局部使用 0.45%酒石酸溴莫尼定滴眼剂可减少飞秒激光预处理引起的瞳孔缩小，并抑制房水 PGE 升高。
