Barros Acsa Nara A B, Dourado Mário Emílio T, Pedrosa Lucia de Fatima C, Leite-Lais Lucia
Department of Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Department of Medicine, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
J Nutr Metab. 2018 Jul 19;2018:5678698. doi: 10.1155/2018/5678698. eCollection 2018.
Oxidative stress is one of the main mechanisms associated with the pathogenesis of amyotrophic lateral sclerosis (ALS). Copper can affect cellular oxidation and lipid metabolism. The aim of this study was to evaluate the association of copper status with lipid profile and functional status in patients with ALS. A cross-sectional study was carried out including 27 patients with ALS (case group) and 26 healthy individuals (control group). Copper status was evaluated by habitual dietary copper intake, plasma copper, and serum ceruloplasmin concentrations. The lipid profile included analysis of serum total cholesterol (TC), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), and triglycerides (TGL). The functional status of patients with ALS was assessed by the ALS Functional Rating Scale-Revised (ALSFRS-R). In the case group, plasma copper was lower compared with the control group (133.9 versus 164.1 g/dL, =0.0001) and was positively correlated with HDL-c (=0.398, =0.044). In the control group, plasma copper was positively correlated with serum ceruloplasmin (=0.646, < 0.001), TC (=0.446, =0.025), LDL-c (=0.445, =0.029), and HDL-c (=0.479, =0.015), and serum ceruloplasmin was positively correlated only with LDL-c (=0.407, =0.043). In the case group, dietary copper intake (=-0.373, < 0.001), plasma copper (=-0.005, =0.033), and TC (=-0.312, =0.001) were inversely associated with the functional status of patients with ALS. In contrast, serum ceruloplasmin (=0.016, =0.044), LDL-c (=0.314, =0.001), HDL-c (=0.308, =0.001), and TGL (=0.062; =0.001) were positively associated with their functional status. In conclusion, this study suggests a disturbance of copper status and its connection with the lipid profile in patients with ALS. Furthermore, copper status and lipid profile may influence the functional status of patients with ALS, standing out as potential biomarkers of disease severity.
氧化应激是与肌萎缩侧索硬化症（ALS）发病机制相关的主要机制之一。铜会影响细胞氧化和脂质代谢。本研究的目的是评估ALS患者铜状态与血脂谱及功能状态之间的关联。开展了一项横断面研究，纳入27例ALS患者（病例组）和26名健康个体（对照组）。通过习惯性膳食铜摄入量、血浆铜和血清铜蓝蛋白浓度评估铜状态。血脂谱包括血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-c）、高密度脂蛋白胆固醇（HDL-c）和甘油三酯（TGL）的分析。通过修订的ALS功能评定量表（ALSFRS-R）评估ALS患者的功能状态。在病例组中，与对照组相比血浆铜较低（133.9对164.1μg/dL，P = 0.0001），且与HDL-c呈正相关（r = 0.398，P = 0.044）。在对照组中，血浆铜与血清铜蓝蛋白（r = 0.646，P < 0.001）、TC（r = 0.446，P = 0.025）、LDL-c（r = 0.445，P = 0.029）和HDL-c（r = 0.479，P = 0.015）呈正相关，血清铜蓝蛋白仅与LDL-c呈正相关（r = 0.407，P = 0.043）。在病例组中，膳食铜摄入量（r = -0.373，P < 0.001）、血浆铜（r = -0.005，P = 0.033）和TC（r = -0.312，P = 0.001）与ALS患者的功能状态呈负相关。相反，血清铜蓝蛋白（r = 0.016，P = 0.044）、LDL-c（r = 0.314，P = 0.001）、HDL-c（r = 0.308，P = 0.001）和TGL（r = 0.062；P = 0.001）与他们的功能状态呈正相关。总之，本研究提示ALS患者存在铜状态紊乱及其与血脂谱的关联。此外，铜状态和血脂谱可能影响ALS患者的功能状态，是疾病严重程度的潜在生物标志物。
