青春期前大鼠睾丸受辐照后的剂量和时间相关反应。I. 睾丸间质细胞功能。

Dose and time related responses of the irradiated prepubertal rat testis. I. Leydig cell function.

作者信息

Delic J I, Hendry J H, Morris I D, Shalet S M

出版信息

Int J Androl. 1985 Dec;8(6):459-71. doi: 10.1111/j.1365-2605.1985.tb00859.x.

DOI:10.1111/j.1365-2605.1985.tb00859.x

Abstract

The testes of prepubertal rats were locally irradiated with 300 kVp x-rays to doses of between 1 and 15 Gy. Leydig cell function was assessed between 2 and 36 weeks post-irradiation. Dysfunction was observed at two weeks as evidenced by a reduction in serum levels of testosterone to between 40 and 70% of control, with a threshold dose of about 5 Gy. Endocrine deficiencies in the Leydig cell population were indicated at later times by increased serum levels of LH, although serum testosterone concentrations recovered to control levels. The elevations in serum LH increased with time suggesting progressive Leydig cell failure.

摘要

对青春期前大鼠的睾丸进行局部300 kVp X射线照射，剂量为1至15 Gy。在照射后2至36周评估睾丸间质细胞功能。照射后两周观察到功能障碍，血清睾酮水平降至对照水平的40%至70%，阈值剂量约为5 Gy。后期，尽管血清睾酮浓度恢复到对照水平，但间质细胞群体中的内分泌缺陷表现为血清LH水平升高。血清LH水平随时间升高，提示间质细胞功能逐渐衰竭。