青春期前大鼠睾丸受照射后的剂量和时间相关反应。II. 生精上皮功能。

Dose and time related responses of the irradiated prepubertal rat testis. II. Seminiferous epithelial function.

作者信息

Delic J I, Hendry J H, Morris I D, Shalet S M

出版信息

Int J Androl. 1985 Dec;8(6):484-96. doi: 10.1111/j.1365-2605.1985.tb00861.x.

DOI:10.1111/j.1365-2605.1985.tb00861.x

Abstract

Dose-related effects of radiation upon the seminiferous epithelium were examined in the prepubertal rat. Marked damage to the spermatogenic cell populations was produced by doses of 5 Gy and above. As a result serum levels of FSH were increased, maximum changes being observed at 2 weeks, but levels remaining high even at 36 weeks after irradiation. Serum levels of androgen binding protein (ABP) were inversely related to serum FSH. Above a threshold dose of 5 Gy, serum ABP levels were reduced to between 30-50% of control values, possibly indicating damage to the Sertoli cells. Progression in the degree of testicular failure was indicated at 36 weeks after a dose of 15 Gy by further increases in serum gonadotrophins when compared to earlier times and by the absence of spermatogenesis.

摘要

在青春期前大鼠中研究了辐射对生精上皮的剂量相关效应。5 Gy及以上剂量对生精细胞群体造成了明显损伤。结果，血清促卵泡激素（FSH）水平升高，在2周时观察到最大变化，但即使在照射后36周水平仍居高不下。雄激素结合蛋白（ABP）的血清水平与血清FSH呈负相关。超过5 Gy的阈值剂量后，血清ABP水平降至对照值的30 - 50%之间，这可能表明支持细胞受到了损伤。与早期相比，15 Gy剂量照射后36周时，血清促性腺激素进一步升高且无精子发生，表明睾丸功能衰竭程度加重。