Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 32000, Israel.
Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13261-13265. doi: 10.1002/anie.201807027. Epub 2018 Sep 5.
The first two α-sila-dipeptides, 7 and cyclo-sila-dipeptide 8, were synthesized and characterized by several methods, including X-ray crystallography. Bulky t-BuMe Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a "Si for C switch" in the central α-position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.
前两个 α-硅二肽 7 和环硅二肽 8 通过包括 X 射线晶体学在内的多种方法进行了合成和表征。大体积的叔丁基二甲基硅取代基为合成分子提供了一定的动力学稳定性。7 和 8 是氨基酸或肽的中心 α-位“硅取代碳”的首个实例，其中硅与氨基和羰基都键合。
