Department of Molecular Microbiology and Biotechnology, School of Molecular Cell Biology and Biotechnology,George S. Wise Faculty of Life Sciences, Tel Aviv University⋅, Tel Aviv, 69978, Israel.
Department of Materials Science and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.
Chem Asian J. 2018 Nov 16;13(22):3437-3447. doi: 10.1002/asia.201801007. Epub 2018 Sep 24.
The rapid development of cost-efficient microfluidic devices has received tremendous attention from scientists of diverse fields. The growing potential of utilizing microfluidic platforms has further advanced the ability to integrate existing technology into microfluidic devices. Thus, allowing scientists to approach questions in fundamental fields, such as amyloid research, using new and otherwise unachievable conditions. Amyloids are associated with neurodegeneration and are in the forefront of many research efforts worldwide. The newly emerged microfluidic technology can serve as a novel research tool providing a platform for developing new methods in this field. In this review, we summarize the recent progress in amyloid research using microfluidic approaches. These approaches are driven from various fields, including physical chemistry, electrochemistry, biochemistry, and cell biology. Moreover, the new insights into novel microfluidic approaches for amyloid research reviewed here can be easily modified for other research interests.
具有成本效益的微流控器件的快速发展引起了不同领域科学家的极大关注。利用微流控平台的潜力不断增加，进一步提高了将现有技术集成到微流控器件中的能力。因此，科学家们可以利用新的、以前无法实现的条件来研究基本领域的问题，如淀粉样蛋白研究。淀粉样蛋白与神经退行性变有关，是全球许多研究工作的前沿。新兴的微流控技术可以作为一种新的研究工具，为该领域的新方法提供平台。在这篇综述中，我们总结了使用微流控方法进行淀粉样蛋白研究的最新进展。这些方法来自物理化学、电化学、生物化学和细胞生物学等不同领域。此外，这里综述的用于淀粉样蛋白研究的新型微流控方法的新见解可以很容易地修改用于其他研究兴趣。
