Li Yingcai, Wang Yuqian, Sun Hongyan, Zhang Yan, Li Hui, Cong Xianling, Yin Wanzhong, Song Wenzhi
1 Department of Stomatology, China-Japan Union Hospital of Jilin University , Changchun, China .
2 Scientific Research Center, China-Japan Union Hospital, Jilin University , Changchun, China .
Genet Test Mol Biomarkers. 2018 Aug;22(8):456-464. doi: 10.1089/gtmb.2018.0089.
Numerous studies have estimated the association between matrix metalloproteinases (MMPs) polymorphisms and the risk of oral cancer; the results, however, are inconsistent and conflicting. Therefore, we conducted a meta-analysis to evaluate the association of MMP-1, 2, and 3 polymorphisms with oral cancer risk.
A computerized literature search was conducted of electronic databases and search engines. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for each gene, and the heterogeneity among studies was estimated using the Q-test and I values. Overall and subgroup analyses were undertaken. Statistical analyses were conducted using Review Manager v5.3 and Stata v12.0 software.
Eighteen studies were included in this meta-analysis. For MMP-1(-1607) 1G/2G, a significant association was observed using the recessive genetic model (OR = 1.47; 95% CI = 1.14-1.91; I = 64%, p = 0.003). In the subgroup studies, a significant association was observed in the Asian subgroup (OR = 1.68; 95% CI = 1.42-1.99; I = 17%, p = 0.30 for the recessive model; and OR = 1.59; 95% CI = 1.19-2.13; I = 80%, p < 0.00001 for the allelic contrast model) and in the European subgroup (OR = 0.65; 95% CI = 0.44-0.98; I = 21%, p = 0.26 for the allelic contrast model). No significant associations were observed with either MMP-2(-1306) C/T or MMP-3(-1171) 5A/6A.
The MMP-1(-1607) 1G/2G polymorphism is associated with oral cancer risk, and the 2G allele played different roles in Asian and European populations.
众多研究已估算基质金属蛋白酶（MMPs）基因多态性与口腔癌风险之间的关联；然而，结果并不一致且相互矛盾。因此，我们进行了一项荟萃分析，以评估MMP - 1、2和3基因多态性与口腔癌风险的关联。
通过计算机检索电子数据库和搜索引擎。计算每个基因的比值比（OR）和95%置信区间（CI），并使用Q检验和I值评估研究间的异质性。进行总体和亚组分析。使用Review Manager v5.3和Stata v12.0软件进行统计分析。
本荟萃分析纳入了18项研究。对于MMP - 1（-1607）1G/2G，使用隐性遗传模型观察到显著关联（OR = 1.47；95% CI = 1.14 - 1.91；I = 64%，p = 0.003）。在亚组研究中，在亚洲亚组（隐性模型：OR = 1.68；95% CI = 1.42 - 1.99；I = 17%，p = 0.30；等位基因对比模型：OR = 1.59；95% CI = 1.19 - 2.13；I = 80%，p < 0.00001）和欧洲亚组（等位基因对比模型：OR = 0.65；95% CI = 0.44 - 0.98；I = 21%，p = 0.26）中观察到显著关联。未观察到MMP - 2（-1306）C/T或MMP - 3（-1171）5A/6A与口腔癌有显著关联。
MMP - 1（-1607）1G/2G基因多态性与口腔癌风险相关，且2G等位基因在亚洲和欧洲人群中发挥了不同作用。
