La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Institute of Microbiology, Leibniz Universität Hannover, 30419 Hannover, Germany.
Cell Chem Biol. 2018 Aug 16;25(8):929-930. doi: 10.1016/j.chembiol.2018.08.002.
In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.
在本期《细胞化学生物学》中，Wong 等人（2018 年）鉴定出几种关键线粒体蛋白酶——组织蛋白酶 L 型蛋白酶 P（ClpP）的失调调控因子。这些失调调控因子被发现可引发程序性细胞死亡，并且可能为新型癌症治疗药物的开发提供新的途径。
