两种症状性关节过度活动的亚型：使用潜在类别分析的描述性研究。
Two subtypes of symptomatic joint hypermobility: a descriptive study using latent class analysis.
机构信息
School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia.
Rheumatology Department, Princess Margaret Hospital for Children, Perth, Western Australia, Australia.
出版信息
Arch Dis Child. 2019 Nov;104(11):1099-1101. doi: 10.1136/archdischild-2017-314149. Epub 2018 Aug 17.
OBJECTIVE
To investigate a cohort of children with symptomatic joint hypermobility.
METHODS
Case notes for 318 children with joint hypermobility attending a rheumatology clinic were reviewed for clinical presentation, medical history, psychosocial factors and physical examination findings. Seven key variables were extracted and used as indicator variables in a latent class analysis to estimate the presence and number of subgroups of children with symptomatic joint hypermobility.
RESULTS
Two subgroups with differing clinical presentations were identified accounting for age and gender: an 'athletic-persistent' class (62%) characterised by higher probabilities for recurrent and chronic musculoskeletal pain, and less severe hypermobility; and a 'systemic-profound' class (38%) characterised by generalised hypermobility, recurrent musculoskeletal pain, gastro-oesophageal reflux and motor delay.
CONCLUSION
Findings suggest the presence of two distinct presentations of children with hypermobility. This finding may be important for clinical decision-making and management of this group of children.
目的
研究一组有症状关节过度活动症的儿童。
方法
对 318 名在风湿病诊所就诊的关节过度活动症儿童的病历进行了回顾，以了解其临床表现、病史、社会心理因素和体格检查结果。提取了 7 个关键变量，并将其用作潜在类别分析中的指示变量，以估计有症状关节过度活动症儿童亚组的存在和数量。
结果
确定了两个具有不同临床表现的亚组，分别占年龄和性别：“运动型-持续性”类（62%）表现为反复和慢性肌肉骨骼疼痛的可能性更高，且关节过度活动程度较轻；“全身性-深刻性”类（38%）表现为全身性关节过度活动、反复肌肉骨骼疼痛、胃食管反流和运动迟缓。
结论
研究结果表明，存在两种不同表现形式的过度活动症儿童。这一发现可能对该组儿童的临床决策和管理具有重要意义。
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