来自续随子种子的具有抑制RAW 264.7细胞中一氧化氮产生作用的瑞香烷型二萜类化合物。
Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells.
作者信息
Lee Jin Woo, Jin Qinghao, Jang Hari, Kim Jun Gu, Lee Dongho, Kim Youngsoo, Hong Jin Tae, Lee Mi Kyeong, Hwang Bang Yeon
机构信息
College of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea.
College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
出版信息
Chem Biodivers. 2018 Oct;15(10):e1800144. doi: 10.1002/cbdv.201800144. Epub 2018 Oct 3.
Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 - 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC values in the range of 11.2 - 52.2 μm.
对续随子种子甲醇提取物进行生物活性导向的分离，得到了18种瑞香烷型二萜类化合物，其中包括一种新的化合物——续随子因子L（1）。通过广泛的核磁共振光谱数据（包括二维核磁共振和高分辨电喷雾电离质谱）以及圆二色光谱数据阐明了它们的化学结构。发现所有分离物（1 - 18）均能抑制脂多糖诱导的RAW 264.7巨噬细胞中一氧化氮的产生，其半数抑制浓度值在11.2 - 52.2 μmol范围内。
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