续随子种子中的五种新二萜类化合物。
Five New Diterpenoids from the Seeds of Euphorbia lathyris.
作者信息
Wang Qian, Zhen Yong-Qi, Gao Feng, Huang Shuai, Zhou Xian-Li
机构信息
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P. R. China.
出版信息
Chem Biodivers. 2018 Nov;15(11):e1800386. doi: 10.1002/cbdv.201800386. Epub 2018 Oct 31.
A new premyrsinane-type diterpenoid, premylanin (1), and four new lathyrane-type diterpenoids named Euphorbia Factors L -L (2-5) were isolated from the seeds of Euphorbia lathyris, together with thirteen known ones (6-18). Their structures were elucidated through spectroscopic analyses, including IR, UV, HR-ESI-MS, 1D- and 2D-NMR. The cytotoxicities of compounds 1-4 and 6-18 against HCT116, MCF-7, 786-0, HepG2 cell lines were evaluated, and compound 13 exhibited considerable cytotoxic activities with an IC values of 6.44, 8.43, 15.3, 9.32 μm, respectively.
从续随子种子中分离出一种新的前弥罗松烷型二萜化合物，续随子素（1），以及四种新的瑞香烷型二萜化合物，命名为大戟因子L-L（2-5），同时还分离出13种已知化合物（6-18）。通过红外光谱（IR）、紫外光谱（UV）、高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（1D-和2D-NMR）等光谱分析方法对其结构进行了鉴定。评估了化合物1-4和6-18对HCT116、MCF-7、786-0、HepG2细胞系的细胞毒性，化合物13表现出相当强的细胞毒性活性，其IC值分别为6.44、8.43、15.3、9.32μm。
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