瑞典精神分裂症和双相情感障碍双胞胎研究（STAR）。
The schizophrenia and bipolar twin study in Sweden (STAR).
机构信息
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Norra Stationsgatan 69, SE-11364 Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
出版信息
Schizophr Res. 2019 Feb;204:183-192. doi: 10.1016/j.schres.2018.08.001. Epub 2018 Aug 16.
The schizophrenia and bipolar twin study in Sweden (STAR) is a large nation-wide cohort of monozygotic (MZ) and dizygotic (DZ) same-sex twins with schizophrenia or bipolar disorder and healthy control pairs, extensively characterized with brain imaging, neuropsychological tests, biomarkers, genetic testing, psychiatric symptoms and personality traits. The purpose is to investigate genetic and environmental mechanisms that give rise to schizophrenia and bipolar disorder as well as the intermediate phenotypes. This article describes the design, recruitment, data collection, measures, collected twins' characteristics, diagnostic procedures as well as ongoing and planned analyses. Identification of biomarkers, genetic and epigenetic variation and the development of specific and common endophenotypes for schizophrenia and bipolar disorder are potential gains from this cohort.
瑞典精神分裂症和双相情感障碍双胞胎研究（STAR）是一项大规模的全国性同卵（MZ）和异卵（DZ）同性双胞胎队列研究，包括精神分裂症或双相情感障碍患者及其健康对照组，广泛进行脑影像学、神经心理学测试、生物标志物、基因检测、精神症状和人格特质等方面的特征描述。其目的是研究导致精神分裂症和双相情感障碍的遗传和环境机制，以及中间表型。本文介绍了该队列的设计、招募、数据收集、测量方法、收集的双胞胎特征、诊断程序以及正在进行和计划进行的分析。从该队列中可能获得精神分裂症和双相情感障碍的生物标志物、遗传和表观遗传变异以及特定和常见的内表型的发展。
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