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心肌收缩带坏死与血管通畅性的相关性。分支点处冠状动脉旁路移植吻合术的研究。

Correlation of myocardial contraction band necrosis and vascular patency. A study of coronary artery bypass graft anastomoses at branch points.

作者信息

Hutchins G M, Bulkley B H

出版信息

Lab Invest. 1977 Jun;36(6):642-8.

PMID:301214
Abstract

Eleven patients who died within 1 week of operation and in whom saphenous vein bypass graft anastomoses were located at or extended across coronary artery branch points were studied at autopsy. New surgically introduced narrowings of greater than 75% in one branch of the 13 anastomoses studied were more frequent (six of eight) when the arteriotomy extended into a branch artery than when the arteriotomy ended proximal to the flow divider of the branch point (zero to five). Obstruction was most frequently caused by suture compression of the arterial lumen. In five of the six anastomoses, where one branch contained a significant new narrowing and the other did not, a striking difference in the severity of myocardial contraction band necrosis in the distribution of the two arteries was found. In each such case the severe necrosis was in the distribution of the patent branch artery and the obstructed branch had slight or trivial injury. The results are interpreted as showing that myocardium that has the potential for developing contraction band necrosis may not develop it if the reflow phase is suppressed.

摘要

对11例术后1周内死亡且大隐静脉搭桥吻合口位于冠状动脉分支点处或跨越该点的患者进行了尸检研究。在研究的13个吻合口中,当动脉切口延伸至分支动脉时,一个分支出现大于75%的新手术性狭窄更为常见(8例中有6例),而当动脉切口在分支点分流器近端结束时则较少见(0至5例)。梗阻最常见的原因是动脉腔被缝线压迫。在6个吻合口中的5个,其中一个分支有明显的新狭窄而另一个没有,在两条动脉分布区域的心肌收缩带坏死严重程度存在显著差异。在每一个这样的病例中,严重坏死发生在通畅分支动脉的分布区域,而梗阻分支仅有轻微或微不足道的损伤。这些结果被解释为表明,如果再灌注期受到抑制,有发生收缩带坏死潜能的心肌可能不会发生坏死。

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