Watanabe T, Saito H
Microbiol Immunol. 1986;30(2):111-22. doi: 10.1111/j.1348-0421.1986.tb00926.x.
Heat-killed Lactobacillus casei YIT 9018 (LC 9018) cells enhanced the resistance to herpes simplex virus type 1 (HSV-1) in adult mice, but not significantly. The protection of mice against HSV-1 infection and the production of neutralizing antibodies were significantly enhanced by the administration of LC 9018 in combination with inactivated HSV-1 antigen. The optimal enhancement of resistance was seen in mice 14 days after the simultaneous administration of these substances. The resistance to HSV-1 infection in mice could be transferred with peritoneal exudate cells from syngeneic mice previously treated with LC 9018 alone and LC 9018 in combination with inactivated HSV-1 antigen or with thioglycollate broth, whereas the transfer of peritoneal exudate cells induced by thioglycollate broth alone and of spleen cells induced by LC 9018 in combination with thioglycollate broth or by thioglycollate broth alone was not effective. These results suggest that mouse peritoneal macrophages induced by the administration of LC 9018 in combination with inactivated HSV-1 antigen may play an important role in host defense mechanisms against HSV-1 infection.
热灭活的干酪乳杆菌YIT 9018（LC 9018）细胞可增强成年小鼠对1型单纯疱疹病毒（HSV-1）的抵抗力，但效果不显著。联合给予LC 9018和灭活的HSV-1抗原可显著增强小鼠对HSV-1感染的抵抗力及中和抗体的产生。同时给予这些物质后14天的小鼠，其抵抗力得到最佳增强。小鼠对HSV-1感染的抵抗力可通过来自同基因小鼠的腹腔渗出细胞进行传递，这些同基因小鼠先前单独用LC 9018处理、用LC 9018与灭活的HSV-1抗原联合处理或用巯基乙酸盐肉汤处理，而单独用巯基乙酸盐肉汤诱导的腹腔渗出细胞传递以及用LC 9018与巯基乙酸盐肉汤联合诱导或单独用巯基乙酸盐肉汤诱导的脾细胞传递均无效。这些结果表明，联合给予LC 9018和灭活的HSV-1抗原诱导的小鼠腹腔巨噬细胞可能在宿主抵御HSV-1感染的防御机制中发挥重要作用。
