Guo Yu-Chen, Zhang Shi-Wen, Yuan Quan
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Stem Cells Int. 2018 Jul 8;2018:3712083. doi: 10.1155/2018/3712083. eCollection 2018.
Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling. Deubiquitinases, which are grouped into five families, remove ubiquitin from target proteins and are involved in several cell functions. Importantly, a number of deubiquitinases mediate bone remodeling through regulating differentiation and/or function of osteoblast and osteoclasts. In this review, we review the functions and mechanisms of deubiquitinases in mediating bone remodeling.
骨重塑对于骨稳态至关重要，它受多种因素和机制的调控。在过去几年中，研究强调了泛素依赖性蛋白水解系统在调节骨重塑中的作用。去泛素化酶分为五个家族，可从靶蛋白上去除泛素，并参与多种细胞功能。重要的是，许多去泛素化酶通过调节成骨细胞和破骨细胞的分化和/或功能来介导骨重塑。在本综述中，我们回顾了去泛素化酶在介导骨重塑中的功能和机制。
