Wang Zhilian, Li Zaibo, Li Jing, Wang Chen, Wang Wenhao, Hao Min, Zhao Chengquan
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China.
Department of Pathology, Ohio State Wexner Medical Center, Columbus, OH 43210, USA.
J Cancer. 2018 Jul 16;9(16):2802-2806. doi: 10.7150/jca.25614. eCollection 2018.
: The distribution of human papillomavirus (HPV) genotypes varies by countries and regions. Data regarding HPV genotype distribution for women with cervical intraepithelial neoplasia 2/3 (CIN2/3) are still limited. This study aimed to investigate the distribution of HPV genotypes for women with CIN2/3 in Shanxi province, China. Prior HPV testing/genotyping resulted from women with histologic diagnosis of CIN2/3 were retrospectively collected between August 2011 and August 2016. : A total of 1387 women with a diagnosis of CIN2/3 were included in this study. The average age of the women was 45.7 years and the average time period from HPV testing to histological diagnosis was 0.4 months. The overall high-risk HPV (hrHPV) positive rate was 91.6%. In all tested women, the most commonly detected hrHPV genotype was HPV16 (59.3%) followed by HPV58 (14.4%) and HPV33 (10.0%), while HPV18 was in the 6 position (6.0%). : This is one of the largest studies of HPV genotyping for women with CIN2/3 in China. The prevalence and distribution of HPV genotypes in these Chinese women differed from those in women from Western countries. Our results provide important information for developing specific HPV vaccines for Chinese women.
人乳头瘤病毒（HPV）基因型的分布因国家和地区而异。关于宫颈上皮内瘤变2/3（CIN2/3）女性的HPV基因型分布数据仍然有限。本研究旨在调查中国山西省CIN2/3女性的HPV基因型分布。回顾性收集了2011年8月至2016年8月间组织学诊断为CIN2/3的女性先前的HPV检测/基因分型结果。：本研究共纳入1387例诊断为CIN2/3的女性。这些女性的平均年龄为45.7岁，从HPV检测到组织学诊断的平均时间为0.4个月。总体高危型HPV（hrHPV）阳性率为91.6%。在所有检测的女性中，最常检测到的hrHPV基因型是HPV16（59.3%），其次是HPV58（14.4%）和HPV33（10.0%），而HPV18排在第6位（6.0%）。：这是中国针对CIN2/3女性进行的最大规模的HPV基因分型研究之一。这些中国女性中HPV基因型的流行率和分布与西方国家女性不同。我们的结果为开发针对中国女性的特定HPV疫苗提供了重要信息。
