Chen Si-He, Song Yu-Ying, Gan Ni, Wang Pin-Tian, Yan Kang, Wang Si-Feng, Zu Yue-E, Peng Xiang-Wen
Central Laboratory, Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha 410001, Hunan Province, China.
World J Clin Oncol. 2025 May 24;16(5):105055. doi: 10.5306/wjco.v16.i5.105055.
Human papillomavirus (HPV) infection is a common sexually transmitted disease and a leading cause of cervical, other anogenital, and oropharyngeal cancers. Screening for precancerous lesions is an effective strategy for preventing HPV-related tumors. Although HPV vaccination has significantly reduced the incidence of cervical cancer, achieving universal coverage remains challenging because of cost barriers, particularly in economically disadvantaged regions. This review provides an update of HPV infection characteristics, screening methods, and strategies tailored to low-resource settings. We also discuss the global burden of HPV-related diseases, regional disparities in the implementation of screening, and future research directions. By examining the current challenges and opportunities, this review aims to inform policymakers and healthcare providers in designing effective, affordable, and scalable screening programs.
人乳头瘤病毒（HPV）感染是一种常见的性传播疾病，也是宫颈癌、其他肛门生殖器癌和口咽癌的主要病因。筛查癌前病变是预防HPV相关肿瘤的有效策略。尽管HPV疫苗接种已显著降低了宫颈癌的发病率，但由于成本障碍，实现普遍覆盖仍然具有挑战性，尤其是在经济弱势地区。本综述提供了HPV感染特征、筛查方法以及针对资源匮乏地区的策略的最新信息。我们还讨论了HPV相关疾病的全球负担、筛查实施中的区域差异以及未来的研究方向。通过审视当前的挑战和机遇，本综述旨在为政策制定者和医疗服务提供者设计有效、可负担且可扩展的筛查项目提供参考。
