职业性接触面粉粉尘与头颈部癌症风险。
Occupational exposure to flour dust and the risk of head and neck cancer.
机构信息
Institut Curie, PSL Research University, DRCI, Biométrie, Saint-Cloud, France.
Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
出版信息
Am J Ind Med. 2018 Oct;61(10):869-873. doi: 10.1002/ajim.22899. Epub 2018 Aug 19.
BACKGROUND
To investigate the association between head and neck squamous cell cancer (HNSCC) risk and occupational exposure to flour dust in women and men, using data from ICARE, a French population-based case-control study.
METHODS
The analysis included 2053 cases of HNSCC and 3507 controls. Lifelong occupational history was collected. A job-exposure matrix was used to assess exposure to flour dust. Odds-ratios (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking, and asbestos exposure, were estimated with logistic regression models.
RESULTS
Ever exposure to flour dust was associated with elevated ORs in women (OR = 2.15, 95%CI: 1.01 4.55) and in men (OR = 1.55, 95%CI: 1.11 2.17). In women, the risk increased with the probability, the duration, and the cumulative level of exposure. No dose-response relationships were observed in men.
CONCLUSIONS
Although the results were less conclusive in men than in women, overall, these findings provide some support to the hypothesis of a role of flour dust in the occurrence of HNSCC.
背景
为了研究面粉尘职业暴露与头颈部鳞状细胞癌（HNSCC）风险之间的关系，本研究利用法国基于人群的病例对照研究 ICARE 的数据进行了分析。
方法
该分析纳入了 2053 例 HNSCC 病例和 3507 例对照。收集了终生职业史。使用职业暴露矩阵评估面粉尘暴露情况。采用 logistic 回归模型，调整了吸烟、饮酒和石棉暴露因素后，估计了比值比（OR）及其 95%置信区间（CI）。
结果
女性（OR=2.15，95%CI：1.01-4.55）和男性（OR=1.55，95%CI：1.11-2.17）中，曾有面粉尘暴露与 HNSCC 风险增加有关。在女性中，风险随暴露概率、暴露持续时间和累积暴露水平的增加而增加。在男性中未观察到剂量-反应关系。
结论
尽管男性的结果不如女性的结论明确，但总体而言，这些发现为面粉尘在 HNSCC 发生中的作用提供了一些支持。
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