职业性接触纺织粉尘与肺癌风险：来自 ICARE 研究的结果。
Occupational exposure to textile dust and lung cancer risk: Results from the ICARE Study.
机构信息
CESP, Fac. de Médecine-Univ. Paris-Sud, Fac. de Médecine-UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.
International Agency for Research on Cancer (IARC), Lyon Cedex 08, France.
出版信息
Am J Ind Med. 2018 Mar;61(3):216-228. doi: 10.1002/ajim.22799. Epub 2017 Dec 27.
BACKGROUND
To investigate the association of lung cancer with occupational exposure to textile dust and specifically to cotton dust in the population-based case-control study ICARE.
METHODS
Lifelong occupational history of 2926 cases and 3555 controls was collected using standardized questionnaires, with specific questions for textile dust exposure. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models controlling for confounding factors including smoking and asbestos exposure.
RESULTS
An inverse association between textile dust exposure and lung cancer was found among workers exposed ≥5% of their work time (OR = 0.80, 95%CI = 0.58-1.09), more pronounced for distant exposures (40+ years; up to a 56% reduced risk, statistically significant). The OR of lung cancer was significantly decreased among workers exposed to cotton fibers (OR = 0.70, 95%CI = 0.48-0.97).
CONCLUSIONS
Our results provide some evidence of a decreased risk of lung cancer associated with exposure to textile dust, particularly cotton.
背景
为了在基于人群的病例对照研究 ICARE 中研究肺癌与纺织粉尘职业暴露的关系，特别是与棉尘的关系。
方法
使用标准化问卷收集了 2926 例病例和 3555 例对照者的终生职业史，并针对纺织粉尘暴露提出了具体问题。使用包含吸烟和石棉暴露等混杂因素的非条件逻辑回归模型估计了比值比（OR）和 95%置信区间（CI）。
结果
在暴露于纺织粉尘≥5%的工作时间的工人中（OR=0.80，95%CI=0.58-1.09），发现纺织粉尘暴露与肺癌之间存在反比关系，对于远距离暴露（40 年以上；风险降低高达 56%，具有统计学意义），这种反比关系更为明显。暴露于棉纤维的工人患肺癌的风险显著降低（OR=0.70，95%CI=0.48-0.97）。
结论
我们的结果提供了一些证据表明，接触纺织粉尘，特别是棉尘，与肺癌风险降低有关。
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