Samara Verena, Sampson Jacinda, Muppidi Srikanth
Department of Neurology and Neurosciences, Stanford Medical Center, Palo Alto, CA.
J Clin Neuromuscul Dis. 2018 Sep;20(1):35-40. doi: 10.1097/CND.0000000000000221.
To describe the variability of fibroblast growth factor receptor 3 (FGFR3) antibody titers in a small series of patients.
We performed a retrospective review of patients with neuropathy and positive FGFR3 antibodies.
We report 7 patients (3 women) with an age range 44-81 years. Symptoms were acute onset in 3 and subacute onset in 4 patients. Five had neuropathic pain. Examination revealed normal large fiber function to mild/moderate predominantly sensory neuropathy and ataxia in one patient. Electrodiagnostic studies revealed normal large fiber function (3), demyelinating neuropathy (1), and mild/moderate axonal neuropathy (3). Four patients had high and 3 patients had low FGFR3 titers. Repeat testing revealed absence of antibodies in 2 patients and a significant reduction in one patient without any intervening immunotherapy.
Our case series highlights the variability and inconsistency in FGFR3 antibody titers through enzyme-linked immunosorbent assay testing. These antibody titers should always be interpreted with caution in clinical context.
描述一小部分患者中纤维母细胞生长因子受体3（FGFR3）抗体滴度的变异性。
我们对患有神经病变且FGFR3抗体呈阳性的患者进行了回顾性研究。
我们报告了7例患者（3名女性），年龄在44至81岁之间。3例症状为急性起病，4例为亚急性起病。5例有神经性疼痛。检查发现1例患者大纤维功能正常至轻度/中度以感觉神经病变和共济失调为主。电诊断研究显示大纤维功能正常（3例）、脱髓鞘性神经病变（1例）和轻度/中度轴索性神经病变（3例）。4例患者FGFR3滴度高，3例患者滴度低。重复检测显示2例患者抗体消失，1例患者未经任何干预性免疫治疗抗体显著降低。
我们的病例系列通过酶联免疫吸附测定试验突出了FGFR3抗体滴度的变异性和不一致性。在临床背景下，这些抗体滴度的解读应始终谨慎。
