Draelos Zoe Diana, Levy Stanley B, Lutrario Celeste, Gunt Hemali
J Drugs Dermatol. 2018 Aug 1;17(8):908-913.
Unique whole formula nature-based sensitive skin products are formulated to minimize irritation while providing conditioning and soothing benefits to clinically diagnosed sensitive skin.
To evaluate and compare the efficacy and tolerability of a regimen of cleanser containing natural oils, beeswax, and witch hazel, and day & night creams containing natural oils, glycerin, and botanical anti-inflammatories (NR); and a synthetic dermatologist-recommended regimen of cetyl alcohol, sodium lauryl sulphate-containing cleanser and glycerin, polyisobutene-containing lotion (CR) in clinically diagnosed sensitive skin resulting from eczema/atopic dermatitis, rosacea, or cosmetic intolerance.
120 subjects were randomized to receive either NR or CR, twice daily for 4 weeks in this double-blind study. Blinded investigator-rated and subject-rated overall skin appearance was assessed using a 5-point scale (0=none, 4=severe) at baseline, 2 weeks, and 4 weeks. Noninvasive skin assessments for skin hydration and skin barrier function were made by corneometry and TEWL, respectively.
NR resulted in a 34% improvement from baseline in investigator-rated overall skin appearance (P less than 0.001); and CR resulted in a 4% improvement. Similar NR and CR results were found in the other efficacy parameters: tactile and visual smoothness, clarity, and radiance. Both regimens improved barrier function from baseline to week 4 (17%, 15%; NR, CR, P equals NS). NR maintained hydration from baseline to week 4 while CR increased hydration by 21% (P less than 0.001). No clinically significant tolerability issues were reported in either regimen at week 4.
The study demonstrated that NR was effective, well tolerated, and superior to CR in the management of sensitive skin. J Drugs Dermatol. 2018;17(8):908-913.
独特的全配方天然敏感肌产品旨在将刺激降至最低，同时为临床诊断的敏感肌肤提供调理和舒缓功效。
评估并比较含天然油脂、蜂蜡和金缕梅的洁面产品，以及含天然油脂、甘油和植物抗炎成分的日霜和晚霜（NR）；与皮肤科医生推荐的含十六醇、月桂醇硫酸酯钠的洁面产品以及含甘油、聚异丁烯的乳液（CR）的合成护肤方案，用于治疗因湿疹/特应性皮炎、玫瑰痤疮或化妆品不耐受导致的临床诊断敏感肌肤的疗效和耐受性。
在这项双盲研究中，120名受试者被随机分为两组，分别接受NR或CR方案，每日两次，为期4周。在基线、2周和4周时，采用5分制量表（0 = 无，4 = 严重）对研究者评分和受试者评分的整体皮肤外观进行评估。分别通过角质层水合测量仪和经皮水分流失测定仪对皮肤水合作用和皮肤屏障功能进行无创皮肤评估。
与基线相比，NR使研究者评分的整体皮肤外观改善了34%（P < 0.001）；CR使皮肤外观改善了4%。在其他功效参数方面，NR和CR的结果相似：触觉和视觉上的光滑度、清晰度和光泽度。两种方案从基线到第4周均改善了皮肤屏障功能（分别为17%、15%；NR、CR，P = 无显著差异）。NR从基线到第4周保持了皮肤水合作用，而CR使皮肤水合作用增加了21%（P < 0.001）。在第4周时，两种方案均未报告有临床显著的耐受性问题。
该研究表明，在敏感肌肤管理方面，NR有效、耐受性良好且优于CR。《药物皮肤病学杂志》。2018年；17(8):908 - 913。
