J Drugs Dermatol. 2020 Dec 1;19(12):1181-1183. doi: 10.36849/JDD.2020.5522.
Patients with sensitive skin find topical retinoid use for anti-aging purposes challenging due to irritation. Bakuchiol, a meroterpene from the Psoralea corylifolia seed, has retinol functionality through retinol-like regulation of gene expression.
This research examined the tolerability, efficacy, and barrier effects of a nature-based bakuchiol-containing cleanser and moisturizer in subjects with sensitive skin.
60 female subjects Fitzpatrick skin types I–V age 40–65 years with sensitive mild to moderate photodamaged skin were enrolled in this 4 week study. A sensitive skin panel was constructed: 1/3 eczema/atopic dermatitis, 1/3 rosacea, 1/3 cosmetic intolerance syndrome. Subjects used a nature-based cleanser and moisturizer twice daily and underwent transepidermal water loss (TEWL), corneometry, tolerability assessments, and efficacy assessments at baseline, 5–10 minutes post-application, and week 4.
The skin care products were well tolerated and efficacious (P<0.001) in terms of investigator assessed improvement in visual smoothness, tactile smoothness, clarity, radiance, overall appearance, and global anti-aging. Cheek corneometry measurements demonstrated a statistically significant 16% increase in skin moisture content (P<0.001).
A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective in individuals with sensitive skin.J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5522.
由于刺激性，敏感皮肤的患者在抗衰老目的上使用局部维甲酸具有挑战性。来自 Psoralea corylifolia 种子的倍半萜 bakuchiol 通过类视黄醇样调节基因表达具有视黄醇功能。
本研究检查了基于天然的含有 bakuchiol 的清洁剂和保湿剂在敏感皮肤受试者中的耐受性、功效和屏障作用。
60 名女性受试者，年龄在 40-65 岁，皮肤类型为 Fitzpatrick I-V，有敏感的轻度至中度光损伤皮肤，患有敏感皮肤，纳入这项为期 4 周的研究。构建了一个敏感皮肤小组：1/3 特应性皮炎/特应性皮炎，1/3 酒渣鼻，1/3 化妆品不耐受综合征。受试者每天使用两次基于天然的清洁剂和保湿剂，并在基线、应用后 5-10 分钟和第 4 周进行经表皮水分流失 (TEWL)、角质层测量、耐受性评估和功效评估。
该护肤品的耐受性和功效良好 (P<0.001)，表现在评估师评估的视觉光滑度、触觉光滑度、清晰度、光泽度、整体外观和整体抗老化方面的改善。脸颊角质层测量显示皮肤水分含量增加了 16%（P<0.001），具有统计学意义。
含有 bakuchiol 的天然抗衰老保湿剂在敏感皮肤个体中具有良好的耐受性和有效性。J 皮肤病学杂志。2020;19(12)：doi:10.36849/JDD.2020.5522.
