Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao, SAR, China.
The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Psychiatry Res. 2018 Oct;268:392-399. doi: 10.1016/j.psychres.2018.07.003. Epub 2018 Jul 24.
The impact of schizophrenia on quality of life (QOL) is significantly influenced by sociocultural factors. This meta-analysis systematically compared QOL between patients with schizophrenia and healthy controls in China. PubMed, PsycINFO, Embase, Chinese National Knowledge Infrastructure (CNKI), SinoMed and WanFang databases were searched to identify case-control studies. Standardized mean differences (SMDs) and 95% confidence interval (CI) were calculated using random effect models. Eighteen case-control studies comparing QOL between schizophrenia patients (n = 2,425) and healthy controls (n = 2,072) were included in the analyses. Compared with healthy controls, schizophrenia patients had significantly poorer overall QOL [11 studies; SMD:-1.07 (95%CI:-1.44, -0.70), P < 0.001] as well as in the physical, psychological, social and environmental QOL domains. Subgroup analyses revealed that poorer QOL was significantly associated with diagnostic criteria, study location, female gender, older age and inpatient status. Older schizophrenia patients had lower physical and psychological QOL, while inpatients had lower psychological QOL. In conclusion, compared with healthy controls, schizophrenia patients in China have significantly lower QOL.
精神分裂症对生活质量（QOL）的影响受到社会文化因素的显著影响。本荟萃分析系统比较了中国精神分裂症患者与健康对照者的 QOL。通过检索 PubMed、PsycINFO、Embase、中国知网（CNKI）、中国生物医学文献数据库（SinoMed）和万方数据库，确定了病例对照研究。使用随机效应模型计算标准化均数差（SMD）和 95%置信区间（CI）。纳入了 18 项比较精神分裂症患者（n=2425）和健康对照者（n=2072）之间 QOL 的病例对照研究。与健康对照组相比，精神分裂症患者的总体 QOL 明显较差[11 项研究；SMD：-1.07（95%CI：-1.44，-0.70），P<0.001]，以及在身体、心理、社会和环境 QOL 领域。亚组分析表明，较差的 QOL 与诊断标准、研究地点、女性、年龄较大和住院状态显著相关。年龄较大的精神分裂症患者的身体和心理 QOL 较低，而住院患者的心理 QOL 较低。总之，与健康对照组相比，中国精神分裂症患者的 QOL 明显较低。
