Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Sichuan Center of Disease Control and Prevention, Chengdu, Sichuan, China.
Acta Neurol Scand. 2018 Dec;138(6):541-547. doi: 10.1111/ane.13016. Epub 2018 Sep 7.
To explore the prevalence and risk factors of depression and anxiety in patients with convulsive epilepsy (PWE) in rural West China.
PWE from rural West China were evaluated for depression and anxiety with the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E; Chinese version) and the Generalized Anxiety Disorder-7 (GAD-7; Chinese version). We also assessed their quality of life using the Quality of Life in Epilepsy Inventory (QOLIE-31) and their level of social support using the Social Support Rating Scale (SSRS). We used logistic regression analysis to identify independent risk factors of depression and anxiety and analysis of variance (ANOVA) to investigate the association between quality of life and depression and anxiety.
Of the 458 PWE in our study, 33.4% have anxiety and 52.6% have depression. SSRS (P = 0.03) and seizure frequency (P = 0.007) are independent risk factors of anxiety, and annual income of the patients (P < 0.001) is an independent risk factor of depression. PWE with both depression and anxiety have significantly lower QOLIE-31 total and subtotal scores.
PWE have a high prevalence of depression and anxiety in rural West China, which may be impacting their quality of life. PWE with depression and anxiety got a worse quality of life, and depression had a greater impact on quality of life for PWE than anxiety. The risk factors of depression and anxiety include seizure frequency and social support, while annual income is an additional risk factor of depression. Identifying risk factors early may be helpful in the timely management of these symptoms.
探讨中国西部农村地区癫痫患者（PWE）抑郁和焦虑的患病率及其危险因素。
采用神经障碍性癫痫抑郁评定量表（C-NDDI-E；中文版）和广泛性焦虑症 7 项量表（GAD-7；中文版）对来自中国西部农村的 PWE 进行抑郁和焦虑评估。我们还使用癫痫患者生活质量量表（QOLIE-31）评估他们的生活质量，使用社会支持评定量表（SSRS）评估他们的社会支持水平。我们使用逻辑回归分析来识别抑郁和焦虑的独立危险因素，并使用方差分析（ANOVA）来探讨生活质量与抑郁和焦虑之间的关系。
在我们的研究中，458 名 PWE 中有 33.4%有焦虑，52.6%有抑郁。SSRS（P = 0.03）和发作频率（P = 0.007）是焦虑的独立危险因素，而患者的年收入（P < 0.001）是抑郁的独立危险因素。同时患有抑郁和焦虑的 PWE 的 QOLIE-31 总分和各分项得分明显较低。
中国西部农村地区的 PWE 抑郁和焦虑患病率较高，这可能会影响他们的生活质量。同时患有抑郁和焦虑的 PWE 的生活质量更差，抑郁对 PWE 的生活质量影响大于焦虑。抑郁和焦虑的危险因素包括发作频率和社会支持，而年收入是抑郁的另一个危险因素。早期识别这些危险因素可能有助于及时管理这些症状。
