Vellucci S V, Webster R A
Pharmacol Biochem Behav. 1986 Apr;24(4):823-7. doi: 10.1016/0091-3057(86)90418-1.
The effects of intracerebroventricular (ICV) beta-carboline carboxylic acid ethyl ester (beta-CCE) and its free acid on the protective effects of diazepam against leptazol- and R05-3663-induced convulsions were investigated in mice and compared with their effects on the antileptazol effect of sodium valproate, in an attempt to demonstrate a specific central effect of beta-CCE on benzodiazepine function. The results show that a small dose (1 microgram) of beta-CCE but not its free acid (in doses of up to 100 micrograms) was able to reverse the protective effects of diazepam against leptazol- and R05-3663-induced convulsions, whereas the effects of sodium valproate, a nonbenzodiazepine anticonvulsant, could not be reversed by these beta-carboline derivatives.
在小鼠中研究了脑室内注射β-咔啉羧酸乙酯（β-CCE）及其游离酸对安定抗戊四氮和R05-3663诱导惊厥的保护作用的影响，并将其与它们对丙戊酸钠抗戊四氮作用的影响进行比较，以试图证明β-CCE对苯二氮䓬功能的特定中枢作用。结果表明，小剂量（1微克）的β-CCE而非其游离酸（剂量高达100微克）能够逆转安定对戊四氮和R05-3663诱导惊厥的保护作用，而丙戊酸钠（一种非苯二氮䓬类抗惊厥药）的作用不能被这些β-咔啉衍生物逆转。
