Vellucci S V, Webster R A
Eur J Pharmacol. 1981 Dec 3;76(2-3):255-9. doi: 10.1016/0014-2999(81)90509-4.
Three possible endogenous ligands for benzodiazepine receptors, beta-carboline-3-carboxylic acid ethyl ester (beta CCE), tryptophylglycine (Trp-Gly) and ACTH peptides, have been tested, following intracerebroventricular (i.c.v.) administration in mice, for their direct effects on the CNS and the modification of diazepam's antileptazol activity. Whilst beta CCE and ACTH both reduced diazepam's antileptazol activity, only beta CCE had direct stimulant effects. Trp-Gly produced sedation and augmented the antileptazol effect of diazepam. Despite these differing effects, it remains possible that the endogenous ligand for the benzodiazepine receptors has a tryptophan-like structure.
对三种可能的苯二氮䓬受体内源性配体，即β-咔啉-3-羧酸乙酯（βCCE）、色氨酰甘氨酸（Trp-Gly）和促肾上腺皮质激素（ACTH）肽，在小鼠脑室内（i.c.v.）给药后，测试了它们对中枢神经系统的直接作用以及对安定抗惊厥活性的影响。虽然βCCE和ACTH都降低了安定的抗惊厥活性，但只有βCCE有直接的兴奋作用。Trp-Gly产生镇静作用并增强了安定的抗惊厥作用。尽管有这些不同的作用，但苯二氮䓬受体的内源性配体仍有可能具有色氨酸样结构。
