Shearman G T, Stenfors C
Pharmacol Biochem Behav. 1986 Apr;24(4):861-3. doi: 10.1016/0091-3057(86)90426-0.
Bremazocine dose-dependently induced backwards walking behavior in rats after its SC injection. Only the (-) but not the (+) enantiomer induced backwards walking. Pretreatment with either naloxone or MR 2266 reduced the bremazocine-induced backwards walking. MR 2266 was at least ten times more potent than naloxone. These findings suggest that bremazocine-induced backwards walking is mediated via an agonistic action of the drug with opioid kappa receptors. The data may contribute to the discussion concerning opioid kappa receptors and the psychotomimetic effects of some opioid analgesic drugs.
布雷马佐辛皮下注射后能剂量依赖性地诱导大鼠出现向后行走行为。只有（-）对映体而非（+）对映体能诱导向后行走。用纳洛酮或MR 2266预处理可减少布雷马佐辛诱导的向后行走。MR 2266的效力至少比纳洛酮强十倍。这些发现表明，布雷马佐辛诱导的向后行走是通过该药物与阿片κ受体的激动作用介导的。这些数据可能有助于有关阿片κ受体和某些阿片类镇痛药拟精神病作用的讨论。
