Fuller R W, Leander J D
J Pharm Pharmacol. 1984 May;36(5):345-6. doi: 10.1111/j.2042-7158.1984.tb04392.x.
Bremazocine at doses of 0.01 mg kg-1 s.c., and higher, increased serum corticosterone concentration several-fold in rats. The increase occurred within 20 min, was maximum at 40-60 min and subsided after 120 min. Pretreatment with naloxone (1-10 mg kg-1 s.c.) antagonized the corticosterone increase. These data support the view that kappa-opioid agonist activity of bremazocine mediated the corticosterone increase.
皮下注射剂量为0.01毫克/千克及更高剂量的布瑞马佐辛，可使大鼠血清皮质酮浓度增加数倍。这种增加在20分钟内出现，40 - 60分钟时达到最大值，120分钟后消退。用纳洛酮（皮下注射1 - 10毫克/千克）预处理可拮抗皮质酮的增加。这些数据支持布瑞马佐辛的κ-阿片受体激动剂活性介导了皮质酮增加这一观点。
