Department of Oncology, Centre Georges François Leclerc, 1 rue Professeur Marion, 21000, Dijon, France.
Department of Radiology, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN, 55455, USA.
BMC Cancer. 2018 Aug 20;18(1):839. doi: 10.1186/s12885-018-4725-7.
Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23-31 months. There are several treatment options including chemotherapy and sometimes endocrine therapy. Currently, there is no standard treatment for patients with MBC who have already benefited from anthracyclines and taxanes therapy. Many drugs like capecitabine, eribulin, gemcitabine, vinorelbin and liposomal doxorubicin are conventionally used as monotherapy. One important complication from MBC is life threating visceral crisis that needs a fast-effective treatment.
We report here a case of an evolution of metastatic breast cancer with lymphangitic carcinomatosis after taxane based chemotherapy and endocrine therapy. This 37-year-old woman was referred to our hospital with complaints of dyspnea and dry cough. There was clinical concern for visceral crisis and a chemotherapy with eribulin was initiated. Pulmonary lymphangitic carcinomatosis disappeared and the patient achieved a good partial response.
We reported a case of rapid, positive treatment response using eribulin on metastatic breast cancer with visceral crisis and we could quoted others. Therefore, eribulin may be an appropriate chemotherapeutic option in instances requiring rapid symptom control.
转移性乳腺癌（MBC）是一种无法治愈的疾病，预后不良，中位总生存期为 23-31 个月。有几种治疗选择，包括化疗，有时还有内分泌治疗。目前，对于已经受益于蒽环类和紫杉烷类治疗的 MBC 患者，尚无标准治疗方法。卡培他滨、艾立布林、吉西他滨、长春瑞滨和脂质体多柔比星等许多药物通常作为单药治疗。MBC 的一个重要并发症是威胁生命的内脏危机，需要快速有效的治疗。
我们在此报告一例转移性乳腺癌伴淋巴管癌病的病例，该患者在接受基于紫杉烷的化疗和内分泌治疗后发生了这种疾病。这名 37 岁女性因呼吸困难和干咳就诊，临床怀疑有内脏危机，开始使用艾立布林进行化疗。肺淋巴管癌病消失，患者获得了良好的部分缓解。
我们报告了一例转移性乳腺癌伴内脏危机患者使用艾立布林进行快速、积极治疗的病例，我们可以引用其他病例。因此，在需要快速控制症状的情况下，艾立布林可能是一种合适的化疗选择。
