Wang Yueqi, Su Minggang, Li Lin
Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China.
Medicine (Baltimore). 2019 Oct;98(41):e17446. doi: 10.1097/MD.0000000000017446.
The infiltration of tumor cells to pulmonary lymphatic system, as known as pulmonary lymphangitis carcinomatosis (PLC), is a rare presentation of pulmonary metastases.
We reported a case of a 66-year-old man after surgery, chemotherapy, and radiation therapy for colon cancer. Two months after these therapies, the patient complained of nonproductive cough for 1 week.
18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) scanning revealed increased FDG uptake along the thickened bronchovascular bundles, in bilaterally scattered ground-glass opacities and in mediastinal lymphadenopathy. The transbronchial biopsy and pathological study confirmed the diagnosis of PLC.
Antineoplastic treatment (cetuximab) were administered after the patient was diagnosed with PLC.
The patient died of respiratory failure within 3 months after the onset of his symptom.
18F-FDG PET/CT play an important role in identifying PLC, in selecting possible biopsy sites, and in accessing the extent of metastatic disease.
肿瘤细胞浸润至肺淋巴系统，即所谓的肺淋巴管癌病（PLC），是肺转移的一种罕见表现。
我们报告了一例66岁男性患者，其接受了结肠癌手术、化疗和放疗。这些治疗后两个月，患者主诉干咳1周。
18F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）显示，沿增厚的支气管血管束、双侧散在的磨玻璃影及纵隔淋巴结处FDG摄取增加。经支气管活检及病理研究确诊为PLC。
患者被诊断为PLC后给予抗肿瘤治疗（西妥昔单抗）。
患者在症状出现后3个月内死于呼吸衰竭。
18F-FDG PET/CT在识别PLC、选择可能的活检部位及评估转移疾病范围方面发挥着重要作用。
